Journey to the other side of the brain: asymmetry in patients with chronic mild or moderate traumatic brain injury.

Autor:	Ross DE; Virginia Institute of Neuropsychiatry, Midlothian, VA 23114, USA., Seabaugh JD; Virginia Institute of Neuropsychiatry, Midlothian, VA 23114, USA., Seabaugh JM; Virginia Institute of Neuropsychiatry, Midlothian, VA 23114, USA., Alvarez C; Virginia Institute of Neuropsychiatry, Midlothian, VA 23114, USA.; Neuroscience Department, Randolph Macon College, Ashland, VA 23005, USA., Ellis LP; Virginia Institute of Neuropsychiatry, Midlothian, VA 23114, USA.; Neuroscience Department, Randolph Macon College, Ashland, VA 23005, USA., Powell C; Virginia Institute of Neuropsychiatry, Midlothian, VA 23114, USA.; Virginia Commonwealth University, Medical College of Virginia, Richmond, VA 23219, USA., Reese C; Virginia Institute of Neuropsychiatry, Midlothian, VA 23114, USA.; Neuroscience Department, University of North Carolina at Wilmington, Wilmington, NC 28403, USA., Cooper L; Virginia Institute of Neuropsychiatry, Midlothian, VA 23114, USA.; Neuroscience Department, Virginia Polytechnic Institute & State University, Blacksburg, VA 24061, USA., Shepherd K; Virginia Institute of Neuropsychiatry, Midlothian, VA 23114, USA.; Neuroscience Department, James Madison University, Harrisonburg, VA 22807, USA., Alzheimer's Disease Neuroimaging Initiative FT; Virginia Institute of Neuropsychiatry, Midlothian, VA 23114, USA.; Neuroscience Department, Randolph Macon College, Ashland, VA 23005, USA.; Virginia Commonwealth University, Medical College of Virginia, Richmond, VA 23219, USA.; Neuroscience Department, University of North Carolina at Wilmington, Wilmington, NC 28403, USA.; Neuroscience Department, Virginia Polytechnic Institute & State University, Blacksburg, VA 24061, USA.; Neuroscience Department, James Madison University, Harrisonburg, VA 22807, USA.
Jazyk:	angličtina
Zdroj:	Concussion (London, England) [Concussion] 2023 Jan 31; Vol. 8 (1), pp. CNC101. Date of Electronic Publication: 2023 Jan 31 (Print Publication: 2022).
DOI:	10.2217/cnc-2022-0003
Abstrakt:	Aim: Patients with chronic mild or moderate traumatic brain injury have some regions of brain atrophy (including cerebral white matter) but even more regions of abnormal brain enlargement (including other cerebral regions). Hypothesis: Ipsilateral injury and atrophy cause the eventual development of contralateral compensatory hypertrophy. Materials & Methods: 50 patients with mild or moderate traumatic brain injury were compared to 80 normal controls (n = 80) with respect to MRI brain volume asymmetry. Asymmetry-based correlations were used to test the primary hypothesis. Results: The group of patients had multiple regions of abnormal asymmetry. Conclusion: The correlational analyses supported the conclusion that acute injury to ipsilateral cerebral white matter regions caused atrophy, leading eventually to abnormal enlargement of contralateral regions due to compensatory hypertrophy. Competing Interests: The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed (© 2023 Virginia Institute of Neuropsychiatry.)
Databáze:	MEDLINE
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