Effects of naturally acquired gastrointestinal nematode infection on bovine viral diarrhea virus vaccine-directed antibody response in western Canadian feedlot cattle.

Autor:	De Seram EL; Department of Large Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, Saskatchewan S7N 5B4 (Seram, Campbell, Ekanayake, Gesy, Uehlinger); Merck Animal Health Canada, Intervet Canada Corp., 16750 Trans Canada Hwy, Kirkland, Quebec H9H 4M7 (Pollock); Faculty of Veterinary Medicine, University of Calgary, 3280 Hospital Drive NW, Calgary, Alberta T2N 4Z6 (Gilleard); Department of Animal and Poultry Science, Agriculture building, University of Saskatchewan, 51 Campus Drive, Saskatoon, Saskatchewan S7N 5A8 (Penner)., Campbell JR; Department of Large Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, Saskatchewan S7N 5B4 (Seram, Campbell, Ekanayake, Gesy, Uehlinger); Merck Animal Health Canada, Intervet Canada Corp., 16750 Trans Canada Hwy, Kirkland, Quebec H9H 4M7 (Pollock); Faculty of Veterinary Medicine, University of Calgary, 3280 Hospital Drive NW, Calgary, Alberta T2N 4Z6 (Gilleard); Department of Animal and Poultry Science, Agriculture building, University of Saskatchewan, 51 Campus Drive, Saskatoon, Saskatchewan S7N 5A8 (Penner)., Pollock CM; Department of Large Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, Saskatchewan S7N 5B4 (Seram, Campbell, Ekanayake, Gesy, Uehlinger); Merck Animal Health Canada, Intervet Canada Corp., 16750 Trans Canada Hwy, Kirkland, Quebec H9H 4M7 (Pollock); Faculty of Veterinary Medicine, University of Calgary, 3280 Hospital Drive NW, Calgary, Alberta T2N 4Z6 (Gilleard); Department of Animal and Poultry Science, Agriculture building, University of Saskatchewan, 51 Campus Drive, Saskatoon, Saskatchewan S7N 5A8 (Penner)., Ekanayake S; Department of Large Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, Saskatchewan S7N 5B4 (Seram, Campbell, Ekanayake, Gesy, Uehlinger); Merck Animal Health Canada, Intervet Canada Corp., 16750 Trans Canada Hwy, Kirkland, Quebec H9H 4M7 (Pollock); Faculty of Veterinary Medicine, University of Calgary, 3280 Hospital Drive NW, Calgary, Alberta T2N 4Z6 (Gilleard); Department of Animal and Poultry Science, Agriculture building, University of Saskatchewan, 51 Campus Drive, Saskatoon, Saskatchewan S7N 5A8 (Penner)., Gesy K; Department of Large Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, Saskatchewan S7N 5B4 (Seram, Campbell, Ekanayake, Gesy, Uehlinger); Merck Animal Health Canada, Intervet Canada Corp., 16750 Trans Canada Hwy, Kirkland, Quebec H9H 4M7 (Pollock); Faculty of Veterinary Medicine, University of Calgary, 3280 Hospital Drive NW, Calgary, Alberta T2N 4Z6 (Gilleard); Department of Animal and Poultry Science, Agriculture building, University of Saskatchewan, 51 Campus Drive, Saskatoon, Saskatchewan S7N 5A8 (Penner)., Gilleard JS; Department of Large Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, Saskatchewan S7N 5B4 (Seram, Campbell, Ekanayake, Gesy, Uehlinger); Merck Animal Health Canada, Intervet Canada Corp., 16750 Trans Canada Hwy, Kirkland, Quebec H9H 4M7 (Pollock); Faculty of Veterinary Medicine, University of Calgary, 3280 Hospital Drive NW, Calgary, Alberta T2N 4Z6 (Gilleard); Department of Animal and Poultry Science, Agriculture building, University of Saskatchewan, 51 Campus Drive, Saskatoon, Saskatchewan S7N 5A8 (Penner)., Penner GB; Department of Large Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, Saskatchewan S7N 5B4 (Seram, Campbell, Ekanayake, Gesy, Uehlinger); Merck Animal Health Canada, Intervet Canada Corp., 16750 Trans Canada Hwy, Kirkland, Quebec H9H 4M7 (Pollock); Faculty of Veterinary Medicine, University of Calgary, 3280 Hospital Drive NW, Calgary, Alberta T2N 4Z6 (Gilleard); Department of Animal and Poultry Science, Agriculture building, University of Saskatchewan, 51 Campus Drive, Saskatoon, Saskatchewan S7N 5A8 (Penner)., Uehlinger FD; Department of Large Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, Saskatchewan S7N 5B4 (Seram, Campbell, Ekanayake, Gesy, Uehlinger); Merck Animal Health Canada, Intervet Canada Corp., 16750 Trans Canada Hwy, Kirkland, Quebec H9H 4M7 (Pollock); Faculty of Veterinary Medicine, University of Calgary, 3280 Hospital Drive NW, Calgary, Alberta T2N 4Z6 (Gilleard); Department of Animal and Poultry Science, Agriculture building, University of Saskatchewan, 51 Campus Drive, Saskatoon, Saskatchewan S7N 5A8 (Penner).
Jazyk:	angličtina
Zdroj:	The Canadian veterinary journal = La revue veterinaire canadienne [Can Vet J] 2023 Mar; Vol. 64 (3), pp. 263-267.
Abstrakt:	Objective: To determine how gastrointestinal nematode (GIN) infection, reflected by fecal egg counts and Ostertagia ostertagi serum antibody titers, is associated with the antibody response to bovine viral diarrhea virus type 1 (BVDV-1) vaccine antigen in fall-weaned feedlot cattle from western Canada. Animals: Cross-sectional study with 240 steer calves derived from an auction market. Procedure: At feedlot arrival, calves were given a commercial vaccine containing modified live BVDV-1. Serum neutralization antibody titers against BVDV-1 antigens were determined in individual blood samples collected pre-vaccination and 21 d after vaccination. A modified Wisconsin sugar floatation method was used to obtain individual calf GIN egg counts in fecal samples on arrival. Antibody titers against O. ostertagi were determined using an enzyme-linked immunosorbent assay in on-arrival blood samples. Results: Fecal egg counts and O. ostertagi titers were not associated with vaccine antibody-fold changes. Similarly, fecal egg counts and O. ostertagi titers were not associated with vaccine-induced seroconversion. Conclusions: The relatively low GIN burdens, reflected by the overall low fecal egg counts in these fall-weaned feedlot calves, did not have measurable adverse effects on the humoral immune response to BVDV-1 vaccine antigens. Clinical Relevance: An adequate response to vaccination is important for cattle welfare and productivity. Conditions that negatively affect this response may vary regionally, such as GIN infection. Understanding this is essential. Although subclinical intestinal parasitism did not noticeably affect the antibody response in these steers, higher GIN burdens and actual immune protection from clinical disease remain to be investigated. (Copyright and/or publishing rights held by the Canadian Veterinary Medical Association.)
Databáze:	MEDLINE
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