Personal air pollution exposure and metals in the nasal epithelial lining fluid of COPD patients.

Autor: Zetlen HL; Division of Pulmonary, Critical Care & Sleep Medicine, Beth Israel Deaconess Medical Center, Boston, MA, United States of America., Stanley Lee A; Division of Pulmonary, Critical Care & Sleep Medicine, Beth Israel Deaconess Medical Center, Boston, MA, United States of America., Nurhussien L; Division of Pulmonary, Critical Care & Sleep Medicine, Beth Israel Deaconess Medical Center, Boston, MA, United States of America., Sun W; Division of Pulmonary, Critical Care & Sleep Medicine, Beth Israel Deaconess Medical Center, Boston, MA, United States of America., Kang CM; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, United States of America., Zanobetti A; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, United States of America., Rice MB; Division of Pulmonary, Critical Care & Sleep Medicine, Beth Israel Deaconess Medical Center, Boston, MA, United States of America.
Jazyk: angličtina
Zdroj: Environmental research, health : ERH [Environ Res Health] 2023 Jun 01; Vol. 1 (2), pp. 021002. Date of Electronic Publication: 2023 Mar 01.
DOI: 10.1088/2752-5309/acbbe5
Abstrakt: Sampling of the nasal epithelial lining fluid is a potential method to assess exposure to air pollution within the respiratory tract among high risk populations. We investigated associations of short- and long-term particulate matter exposure (PM) and pollution-related metals in the nasal fluid of people with chronic obstructive pulmonary disease (COPD). This study included 20 participants with moderate-to-severe COPD from a larger study who measured long-term personal exposure to PM 2.5 using portable air monitors and short-term PM 2.5 and black carbon (BC) using in-home samplers for the seven days preceding nasal fluid collection. Nasal fluid was sampled from both nares by nasosorption, and inductively coupled plasma mass spectrometry was used to determine the concentration of metals with major airborne sources. Correlations of selected elements (Fe, Ba, Ni, Pb, V, Zn, Cu) were determined within the nasal fluid. Associations between personal long-term PM 2.5 and seven day home PM 2.5 and BC exposure and nasal fluid metal concentrations were determined by linear regression. Within nasal fluid samples, concentrations of vanadium and nickel ( r = 0.8) and lead and zinc ( r = 0.7) were correlated. Seven day and long-term PM 2.5 exposure were both associated with higher levels of copper, lead, and vanadium in the nasal fluid. BC exposure was associated with higher levels of nickel in the nasal fluid. Levels of certain metals in the nasal fluid may serve as biomarkers of air pollution exposure in the upper respiratory tract.
(© 2023 The Author(s). Published by IOP Publishing Ltd.)
Databáze: MEDLINE
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