Tumor induced osteomalacia from a peripheral mesenchymal tumour of the foot.

Autor: Strydom A; Consultant Foot and Ankle Surgeon, Suite 3A, -2 Level, Westwing, Netcare Sunninghill Hospital, Cnr Nanyuki & Witkoppen Road, Sunninghill, 2157, South Africa. Electronic address: drewstrydom@hotmail.com., Greeff W; Orthopaedic Surgeon, Charlotte Maxeke Johannesburg Academic Hospital (CMJAH), University of the Witwatersrand, Division of Orthopaedic Surgery, South Africa. Electronic address: tingreeff@gmail.com., Ferrao PNF; Orthopaedic Surgeon, Charlotte Maxeke Johannesburg Academic Hospital (CMJAH), University of the Witwatersrand, Division of Orthopaedic Surgery, South Africa; Consultant Foot and Ankle Surgeon, The Orthopaedic Foot and Ankle Unit, Suite 303 Netcare Linksfield Park Clinic, 24 12th Avenue, Orange Grove, 2192, South Africa. Electronic address: paulo@cybersmart.co.za., Saragas NP; Adjunct Professor, University of the Witwatersrand, Division of Orthopaedic Surgery, South Africa; Consultant Foot and Ankle Surgeon, The Orthopaedic Foot and Ankle Unit, Suite 303 Netcare Linksfield Park Clinic, 24 12th Avenue, Orange Grove, 2192, South Africa. Electronic address: saragas@global.co.za.
Jazyk: angličtina
Zdroj: Foot (Edinburgh, Scotland) [Foot (Edinb)] 2023 May; Vol. 55, pp. 101979. Date of Electronic Publication: 2023 Feb 19.
DOI: 10.1016/j.foot.2023.101979
Abstrakt: Tumour induced osteomalacia (TIO) is a rare condition caused by peripheral mesenchymal tumours (PMT) which produce fibroblast-growth factor 23 (FGF23). FGF23 inhibits renal phosphate reabsorption leading to vitamin D resistant osteomalacia. The rarity of the condition and difficulty with isolating the PMT make diagnosis difficult, with delayed treatment leading to significant patient morbidity. We present a case of PMT of the foot with TIO, with a discussion on diagnosis and treatment.
Competing Interests: Conflict of Interest Statement Each author certifies that he or she has no commercial associations (e.g. consultancies, stock ownership, equity interest, patent/licensing arrangements, etc.) that might pose a conflict of interest in connection with the submitted article.
(Copyright © 2023 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: