Clinical and radiological findings of posterior reversible encephalopathy syndrome in children: About 16 children hospitalized in the pediatric department of a Tunisian tertiary care hospital.

Autor: Ajmi H; Department of Pediatrics, Sahloul Teaching Hospital, 4054, Sousse, Tunisia. Electronic address: hd.ajmi@gmail.com., Brahim J; Department of Pediatrics, Sahloul Teaching Hospital, 4054, Sousse, Tunisia., Mabrouk S; Department of Pediatrics, Sahloul Teaching Hospital, 4054, Sousse, Tunisia., Ben Abdallah A; Department of Radiology, Sahloul Teaching Hospital, 4054, Sousse, Tunisia., Zouari N; Department of Pediatrics, Sahloul Teaching Hospital, 4054, Sousse, Tunisia., Majdoub F; Department of Pediatrics, Sahloul Teaching Hospital, 4054, Sousse, Tunisia., Nouir S; Department of Pediatrics, Sahloul Teaching Hospital, 4054, Sousse, Tunisia., Hasni I; Department of Radiology, Sahloul Teaching Hospital, 4054, Sousse, Tunisia., Ben Cheikh Y; Department of Radiology, Sahloul Teaching Hospital, 4054, Sousse, Tunisia., Chemli J; Department of Pediatrics, Sahloul Teaching Hospital, 4054, Sousse, Tunisia., Jemni H; Department of Radiology, Sahloul Teaching Hospital, 4054, Sousse, Tunisia., Abroug S; Department of Pediatrics, Sahloul Teaching Hospital, 4054, Sousse, Tunisia.
Jazyk: angličtina
Zdroj: European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society [Eur J Paediatr Neurol] 2023 Mar; Vol. 43, pp. 18-26. Date of Electronic Publication: 2023 Feb 19.
DOI: 10.1016/j.ejpn.2023.02.003
Abstrakt: Background: Posterior reversible encephalopathy syndrome (PRES) is a clinico-radiological entity most frequently described in young- or middle-aged adults with a rare occurrence among children.
Aim: To determine the clinical, radiological features and outcome of PRES in children admitted to a Tunisian tertiary care pediatric department.
Methods: we retrospectively reviewed records of all children under 18 years old diagnosed with PRES and admitted to the PICU of the Pediatric department of Sahloul University Hospital from January 2000 to August 2021.
Results: Sixteen patients were enrolled in this study. The mean age of the study population at PRES onset was 10 years (range: 4-14 years) and the male female ratio was 3. The most frequent neurological signs were seizures (n = 16 cases), headache (n = 8 cases), and impaired level of consciousness (7 cases). Visual disturbances were found in one patient. Arterial hypertension was the most underlying cause (16 cases). Brain MRI showed vasogenic edema, mostly localized in the parietal (13 cases) and occipital (11 cases) lobes. Moreover, cytotoxic edema (2 cases), pathologic contrast enhancement (1 case), and hemorrhage (3 cases) were isolated on MRI. The outcome after specific management was favorable after the first onset in 13 cases and death occurred in 3 patients. Relapses were observed in 4 patients.
Conclusion: Clinical features presented by children with PRES are variable and non-specific. MRI typically shows reversible posterior cerebral edema. However, in some cases, atypical neuro-imaging findings, such as cytotoxic edema infarction, hemorrhage and contrast enhancement can be observed.
Competing Interests: Declaration of competing interest None.
(© 2023 Published by Elsevier Ltd on behalf of European Paediatric Neurology Society.)
Databáze: MEDLINE
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