Nanomedicine for autophagy modulation in cancer therapy: a clinical perspective.

Autor: López-Méndez TB; NanoBioCel Group, University of the Basque Country (UPV/EHU), Vitoria-Gasteiz, Spain.; Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Vitoria-Gasteiz, Spain., Sánchez-Álvarez M; Area of Cell and Developmental Biology. Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.; Instituto de Investigaciones Biomédicas Alberto Sols (IIB), Madrid, Spain., Trionfetti F; Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy.; National Institute for Infectious Diseases L. Spallanzani IRCCS, Rome, Italy., Pedraz JL; NanoBioCel Group, University of the Basque Country (UPV/EHU), Vitoria-Gasteiz, Spain.; Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Vitoria-Gasteiz, Spain., Tripodi M; Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy.; National Institute for Infectious Diseases L. Spallanzani IRCCS, Rome, Italy., Cordani M; Department of Biochemistry and Molecular Biology, School of Biology, Complutense University, Madrid, Spain. mcordani@ucm.es.; Instituto de Investigaciones Sanitarias San Carlos (IdISSC), Madrid, Spain. mcordani@ucm.es., Strippoli R; Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy. raffaele.strippoli@uniroma1.it.; National Institute for Infectious Diseases L. Spallanzani IRCCS, Rome, Italy. raffaele.strippoli@uniroma1.it., González-Valdivieso J; Department of Radiology, Molecular Imaging Innovations Institute (MI3), Weill Cornell Medicine, New York, USA. juan.gonzalez.valdivieso@uva.es.
Jazyk: angličtina
Zdroj: Cell & bioscience [Cell Biosci] 2023 Mar 04; Vol. 13 (1), pp. 44. Date of Electronic Publication: 2023 Mar 04.
DOI: 10.1186/s13578-023-00986-9
Abstrakt: In recent years, progress in nanotechnology provided new tools to treat cancer more effectively. Advances in biomaterials tailored for drug delivery have the potential to overcome the limited selectivity and side effects frequently associated with traditional therapeutic agents. While autophagy is pivotal in determining cell fate and adaptation to different challenges, and despite the fact that it is frequently dysregulated in cancer, antitumor therapeutic strategies leveraging on or targeting this process are scarce. This is due to many reasons, including the very contextual effects of autophagy in cancer, low bioavailability and non-targeted delivery of existing autophagy modulatory compounds. Conjugating the versatile characteristics of nanoparticles with autophagy modulators may render these drugs safer and more effective for cancer treatment. Here, we review current standing questions on the biology of autophagy in tumor progression, and precursory studies and the state-of-the-art in harnessing nanomaterials science to enhance the specificity and therapeutic potential of autophagy modulators.
(© 2023. The Author(s).)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje