HLA-DMB alleles and haplotypes in Ecuador (Cuenca) Amerindians: Importance for HLA and disease studies.

Autor: Suarez-Trujillo F; Department of Immunology, University Complutense of Madrid, Spain and Instituto de Investigaciones Sanitarias, Hospital Gregorio Marañon, Madrid, Spain., Juarez I; Department of Immunology, University Complutense of Madrid, Spain and Instituto de Investigaciones Sanitarias, Hospital Gregorio Marañon, Madrid, Spain., José Recio-Hoyas M; Department of Immunology, University Complutense of Madrid, Spain and Instituto de Investigaciones Sanitarias, Hospital Gregorio Marañon, Madrid, Spain., Rey D; Department of Immunology, University Complutense of Madrid, Spain and Instituto de Investigaciones Sanitarias, Hospital Gregorio Marañon, Madrid, Spain., Palacio-Gruber J; Department of Immunology, University Complutense of Madrid, Spain and Instituto de Investigaciones Sanitarias, Hospital Gregorio Marañon, Madrid, Spain., Gil-Martin R; Department of Immunology, University Complutense of Madrid, Spain and Instituto de Investigaciones Sanitarias, Hospital Gregorio Marañon, Madrid, Spain., Manuel Martín-Villa J; Department of Immunology, University Complutense of Madrid, Spain and Instituto de Investigaciones Sanitarias, Hospital Gregorio Marañon, Madrid, Spain., Arnaiz-Villena A; Department of Immunology, University Complutense of Madrid, Spain and Instituto de Investigaciones Sanitarias, Hospital Gregorio Marañon, Madrid, Spain. Electronic address: aarnaiz@med.ucm.es.
Jazyk: angličtina
Zdroj: Human immunology [Hum Immunol] 2023 Apr; Vol. 84 (4), pp. 261-262. Date of Electronic Publication: 2023 Mar 02.
DOI: 10.1016/j.humimm.2023.02.004
Abstrakt: HLA-DMB allele frequencies and HLA-DBM-DRB1-DQB1 extended haplotypes were studied for the first time in Amerindians (Cuenca city area, Ecuador). It was found that most common extended haplotypes gathered the most frequent HLA-DRB1 Amerindian alleles. HLA-DMB polymorphism studies may be important to uncover HLA and diseases pathogenesis and also in an extended HLA haplotype frameshift. HLA-DM molecule has a crucial role together with CLIP protein in HLA class II peptide presentation. HLA extended haplotypes including complement and non classical genes alleles are proposed to HLA and disease studies.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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