TOT in combination with solifenacin or intravaginal prasterone in postmenopausal women with mixed urinary incontinence: A retrospective analysis in 112 patients.

Autor: Sala F; Department of Surgical Sciences, Section of Gynecology and Obstetrics, University Tor Vergata, Rome, Italy.; Department of Gynecological and Obstetrics, Sandro Pertini Hospital, Rome, Italy., Loggia M; Department of Surgical Sciences, Section of Gynecology and Obstetrics, University Tor Vergata, Rome, Italy.; Department of Gynecological and Obstetrics, Sandro Pertini Hospital, Rome, Italy., Cardella G; Department of Surgical Sciences, Section of Gynecology and Obstetrics, University Tor Vergata, Rome, Italy.; Department of Gynecological and Obstetrics, Sandro Pertini Hospital, Rome, Italy., Morgani C; Department of Surgical Sciences, Section of Gynecology and Obstetrics, University Tor Vergata, Rome, Italy.; Department of Gynecological and Obstetrics, Sandro Pertini Hospital, Rome, Italy., Grossi G; Department of Gynecological and Obstetrics, Sandro Pertini Hospital, Rome, Italy., Zullo MA; Department of Week-Surgery, Campus Biomedico, University of Rome, Rome, Italy., Valensise HCC; Department of Surgical Sciences, Section of Gynecology and Obstetrics, University Tor Vergata, Rome, Italy., Palazzetti PL; Department of Gynecological and Obstetrics, Sandro Pertini Hospital, Rome, Italy., Schiavi MC; Department of Gynecological and Obstetrics, Sandro Pertini Hospital, Rome, Italy.
Jazyk: angličtina
Zdroj: Lower urinary tract symptoms [Low Urin Tract Symptoms] 2023 May; Vol. 15 (3), pp. 96-101. Date of Electronic Publication: 2023 Mar 04.
DOI: 10.1111/luts.12476
Abstrakt: Objectives: The aim of this study was to compare the efficacy of the transobturator tape (TOT) procedure combined with solifenacin (TOT-S) or prasterone (TOT-P) in postmenopausal women affected by mixed urinary incontinence (MUI) with a predominant stress urinary incontinence component.
Methods: This is a retrospective analysis including 112 patients: 60 patients of the TOT-S group and 52 patients of the TOT-P group. Physical examination, 3-day voiding diary, urodynamic tests, and Vaginal Health Index (VHI) were compared at the beginning of the analysis and after 12 weeks of follow-up (FU). Specific questionnaires were administered to indagate the impact on women's quality of life and sexual function.
Results: After 12 weeks of FU, the detrusor's peak flow pressure was significantly different between the two groups (p = .02). Detrusor overactivity decreased only in the TOT-P group (p = .05). At the end of FU, 58 patients (96.7%) of the TOT-S group and 50 patients (96.2%) of the TOT-P group were dry at the stress test. A significative group difference was observed in urge urinary incontinence (24 h) (p = .01) but not in the mean number of voids (24 h) and urgent micturition events (24 h). VHI improved only in the TOT-P group (12.57 ± 3.80 vs. 19.75 ± 4.13, p < .0001). The questionnaires and Patient Global Index of Improvement (PGI-I) scores showed comparable improvements, while the Female Sexual Function Index improved especially in the TOT-P group (p < .001).
Conclusions: In postmenopausal women with MUI, TOT-P demonstrated the same effectiveness as TOT-S in reducing urinary symptoms. In addition, TOT-P increased VHI and sexual function scores compared with TOT-S.
(© 2023 John Wiley & Sons Australia, Ltd.)
Databáze: MEDLINE
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