The incidence of laboratory-confirmed cases of enteric pathogens in Denmark 2018: a national observational study.

Autor: Svendsen AT; Department of Medicine, Zealand University Hospital, Køge, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.; Department of Infectious Disease Epidemiology and Prevention, Statens Serum Institut, Copenhagen, Denmark., Nielsen HL; Department of Clinical Microbiology, Aalborg University Hospital, Aalborg, Denmark.; Department of Clinical Medicine, Aalborg University, Aalborg, Denmark., Bytzer P; Department of Medicine, Zealand University Hospital, Køge, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Coia JE; Department of Clinical Microbiology, Sydvestjysk Sygehus, Esbjerg, Denmark.; Department of Regional Health Research, University of Southern, Odense, Denmark., Engberg J; Department of Clinical Microbiology, Zealand University Hospital, Slagelse, Denmark., Holt HM; Department of Clinical Microbiology, Odense University Hospital, Odense, Denmark., Lemming L; Department of Clinical Microbiology, Aarhus University Hospital, Denmark., Lomborg S; Department of Clinical Microbiology, Sygehus Sønderjylland, Aabenraa, Denmark., Marmolin ES; Department of Clinical Microbiology, Sygehus Lillebælt, Vejle, Denmark., Olesen BS; Department of Clinical Microbiology, Copenhagen University Hospital Herlev, Copenhagen, Denmark., Andersen LP; Department of Clinical Microbiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Ethelberg S; Department of Infectious Disease Epidemiology and Prevention, Statens Serum Institut, Copenhagen, Denmark.; Department of Public Health, Global Health Section, University of Copenhagen, Copenhagen, Denmark., Engsbro AL; Department of Clinical Microbiology, Zealand University Hospital, Slagelse, Denmark.; Copenhagen University Hospital Hvidovre, Copenhagen, Denmark.
Jazyk: angličtina
Zdroj: Infectious diseases (London, England) [Infect Dis (Lond)] 2023 May; Vol. 55 (5), pp. 340-350. Date of Electronic Publication: 2023 Mar 03.
DOI: 10.1080/23744235.2023.2183253
Abstrakt: Background: Only a subset of enteric pathogens is under surveillance in Denmark, and knowledge on the remaining pathogens detected in acute gastroenteritis is limited. Here, we present the one-year incidence of all enteric pathogens diagnosed in Denmark, a high-income country, in 2018 and an overview of diagnostic methods used for detection.
Methods: All 10 departments of clinical microbiology completed a questionnaire on test methods and provided 2018-data of persons with positive stool samples with Salmonella species, Campylobacter jejuni/coli , Yersinia enterocolitica, Aeromonas species, diarrheagenic Escherichia coli (Enteroinvasive (EIEC), Shiga toxin-producing (STEC), Enterotoxigenic (ETEC), Enteropathogenic (EPEC), and intimin-producing/attaching and effacing (AEEC)) , Shigella species. , Vibrio cholerae, norovirus, rotavirus, sapovirus, adenovirus, Giardia intestinalis, Cryptosporidium species, and Entamoeba histolytica .
Results: Enteric bacterial infections were diagnosed with an incidence of 229.9 cases/100,000 inhabitants, virus had an incidence of 86/100,000 and enteropathogenic parasites of 12.5/100,000. Viruses constituted more than half of diagnosed enteropathogens for children below 2 years and elderly above 80 years. Diagnostic methods and algorithms differed across the country and in general PCR testing resulted in higher incidences compared to culture (bacteria), antigen-test (viruses), or microscopy (parasites) for most pathogens.
Conclusions: In Denmark, the majority of detected infections are bacterial with viral agents primarily detected in the extremes of ages and with few intestinal protozoal infections. Incidence rates were affected by age, clinical setting and local test methods with PCR leading to increased detection rates. The latter needs to be taken into account when interpreting epidemiological data across the country.
Databáze: MEDLINE
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