Utilizing a Questionnaire to Implement a Risk-based Antibiotic Prophylaxis Protocol for Transrectal Prostate Biopsy.

Autor: Gul ZG; Department of Urology, University of Pittsburgh, Pittsburgh, PA., Yu M; Department of Urology, University of Pittsburgh, Pittsburgh, PA., Sharbaugh DR; Department of Urology, University of Pittsburgh, Pittsburgh, PA., Pekala KR; Department of Urology, University of Pittsburgh, Pittsburgh, PA., Lin JY; Department of Urology, University of Pittsburgh, Pittsburgh, PA., Sharbaugh AJ; Department of Urology, University of Pittsburgh, Pittsburgh, PA., Zhu TS; School of Medicine, University of Pittsburgh, Pittsburgh, PA., Worku H; School of Medicine, University of Pittsburgh, Pittsburgh, PA., Armann KM; School of Medicine, University of Pittsburgh, Pittsburgh, PA., Hudson CN; School of Medicine, University of Pittsburgh, Pittsburgh, PA., Hay JM; School of Medicine, University of Pittsburgh, Pittsburgh, PA., Grajales V; Department of Urology, University of Pittsburgh, Pittsburgh, PA., Yabes JG; Department of Medicine, University of Pittsburgh, Pittsburgh, PA., Davies BJ; Department of Urology, University of Pittsburgh, Pittsburgh, PA., Jacobs BL; Department of Urology, University of Pittsburgh, Pittsburgh, PA. Electronic address: jacobsbl2@upmc.edu.
Jazyk: angličtina
Zdroj: Urology [Urology] 2023 May; Vol. 175, pp. 18-24. Date of Electronic Publication: 2023 Mar 02.
DOI: 10.1016/j.urology.2022.11.058
Abstrakt: Objective: To develop and evaluate a risk-based antibiotic prophylaxis protocol for patients undergoing transrectal prostate biopsy.
Methods: We created a risk-based protocol for antibiotic prophylaxis before transrectal prostate biopsy. Patients were screened for infection risk-factors with a self-administered questionnaire. The protocol was implemented from January 1, 2020 to March 31, 2020. We compared patient risk-factors, antibiotic regimens, and 30-day infection rates for patients undergoing transrectal prostate biopsies during the intervention and for a 3-month period before the intervention.
Results: There were 116 prostate biopsies in the preintervention group and 104 in the intervention group. Although there was no significant difference in the number of high-risk patients between the 2 groups (48% vs 55%; P = .33), the percentage of patients treated with augmented prophylaxis decreased from 74% to 45% (P = 0.03). The duration of antibiotic administration and the median number of doses prescribed also decreased significantly. Despite significant decreases in antibiotic use, there were no differences in infection rates (5% vs 5%; P = .90) or sepsis rates (1% vs 2%; P = .60).
Conclusion: We developed a risk-based protocol for prophylactic antibiotics before prostate biopsy. The protocol was associated with less antibiotic use but did not lead to an increase in infectious complications.
(Copyright © 2023 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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