Incidence of LADA and Type 2 Diabetes in Relation to Tobacco Use and Genetic Susceptibility to Type 2 Diabetes and Related Traits: Findings From a Swedish Case-Control Study and the Norwegian HUNT Study.

Autor:	Edstorp J; 1Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden., Ahlqvist E; 2Department of Clinical Sciences in Malmö, Lund University Diabetes Centre, Lund University, Malmö, Sweden., Alfredsson L; 1Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.; 3Center for Occupational and Environmental Medicine, Stockholm, Sweden., Mansour Aly D; 2Department of Clinical Sciences in Malmö, Lund University Diabetes Centre, Lund University, Malmö, Sweden., Grill V; 4Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway., Rasouli B; 1Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.; 5Department of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, MA., Sørgjerd EP; 6HUNT Research Centre, Department of Public Health and Nursing, Norwegian University of Science and Technology, Levanger, Norway.; 7Department of Endocrinology, Clinic of Medicine, St. Olavs Hospital, Trondheim, Norway., Tuomi T; 2Department of Clinical Sciences in Malmö, Lund University Diabetes Centre, Lund University, Malmö, Sweden.; 8Institute for Molecular Medicine Finland, Helsinki University, Helsinki, Finland.; 9Division of Endocrinology, Abdominal Center, Helsinki University Hospital, Helsinki, Finland.; 10Research Program for Diabetes and Obesity, University of Helsinki, Helsinki, Finland.; 11Folkhälsan Research Center, Helsinki, Finland., Åsvold BO; 6HUNT Research Centre, Department of Public Health and Nursing, Norwegian University of Science and Technology, Levanger, Norway.; 7Department of Endocrinology, Clinic of Medicine, St. Olavs Hospital, Trondheim, Norway.; 12K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, Norway., Carlsson S; 1Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Jazyk:	angličtina
Zdroj:	Diabetes care [Diabetes Care] 2023 May 01; Vol. 46 (5), pp. 1028-1036.
DOI:	10.2337/dc22-2284
Abstrakt:	Objective: Smoking and Swedish smokeless tobacco (snus) are associated with latent autoimmune diabetes in adults (LADA) and type 2 diabetes (T2D). Our aim was to investigate whether genetic susceptibility to T2D, insulin resistance (IR), and insulin secretion (IS) aggravate these associations. Research Design and Methods: We used data from two population-based Scandinavian studies with case subjects with LADA (n = 839) and T2D (n = 5,771), matched control subjects (n = 3,068), and 1,696,503 person-years at risk. Pooled, multivariate relative risks (RR) with 95% CI were estimated for smoking/genetic risk scores (T2D-GRS, IS-GRS, and IR-GRS), and ORs for snus or tobacco/GRS (case-control data). We estimated additive (proportion attributable to interaction [AP]) and multiplicative interaction between tobacco use and GRS. Results: The RR of LADA was elevated in high IR-GRS heavy smokers (≥15 pack-years; RR 2.01 [CI 1.30, 3.10]) and tobacco users (≥15 box/pack-years; RR 2.59 [CI 1.54, 4.35]) compared with low IR-GRS individuals without heavy use, with evidence of additive (AP 0.67 [CI 0.46, 0.89]; AP 0.52 [CI 0.21, 0.83]) and multiplicative (P = 0.003; P = 0.034) interaction. In heavy users, there was additive interaction between T2D-GRS and smoking, snus, and total tobacco use. The excess risk conferred by tobacco use did not differ across GRS categories in T2D. Conclusions: Tobacco use may confer a higher risk of LADA in individuals with genetic susceptibility to T2D and insulin resistance, whereas genetic susceptibility does not seem to influence the increased T2D incidence associated with tobacco use. (© 2023 by the American Diabetes Association.)
Databáze:	MEDLINE
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