Differential disruption on glucose and insulin metabolism in two rat models of diet-induced obesity, based on carbohydrates or lipids.

Autor: de María Márquez Álvarez C; Laboratory for Research in Metabolic and Infectious Diseases, Multidisciplinary Academic Division of Comalcalco, Juarez Autonomous University of Tabasco, Ranchería Sur, Cuarta Sección, C.P., 86650, Comalcalco, Tabasco, México., Gómez-Crisóstomo NP; Laboratory for Research in Metabolic and Infectious Diseases, Multidisciplinary Academic Division of Comalcalco, Juarez Autonomous University of Tabasco, Ranchería Sur, Cuarta Sección, C.P., 86650, Comalcalco, Tabasco, México., De la Cruz-Hernández EN; Laboratory for Research in Metabolic and Infectious Diseases, Multidisciplinary Academic Division of Comalcalco, Juarez Autonomous University of Tabasco, Ranchería Sur, Cuarta Sección, C.P., 86650, Comalcalco, Tabasco, México., Zazueta C; Departamento de Biomedicina Cardiovascular, Instituto Nacional de Cardiología, I. Ch. 14080, CDMX, México., Aguilar-Gamas CF; Laboratory for Research in Metabolic and Infectious Diseases, Multidisciplinary Academic Division of Comalcalco, Juarez Autonomous University of Tabasco, Ranchería Sur, Cuarta Sección, C.P., 86650, Comalcalco, Tabasco, México., Martínez-Abundis E; Laboratory for Research in Metabolic and Infectious Diseases, Multidisciplinary Academic Division of Comalcalco, Juarez Autonomous University of Tabasco, Ranchería Sur, Cuarta Sección, C.P., 86650, Comalcalco, Tabasco, México. lulimtz@yahoo.com.mx.
Jazyk: angličtina
Zdroj: Molecular and cellular biochemistry [Mol Cell Biochem] 2023 Nov; Vol. 478 (11), pp. 2481-2488. Date of Electronic Publication: 2023 Mar 03.
DOI: 10.1007/s11010-023-04677-4
Abstrakt: Obesity is a relevant health public issue and is the main factor for glucose metabolism dysregulation and diabetes progression; however, the differential role of a high-fat diet or high sugar diet consumption on glucose metabolism and insulin processing is not well understood and has been scarcely described. Our research aimed to analyze the effects of chronic consumption of both high sucrose and high-fat diets on glucose and insulin metabolism regulation. Wistar rats were fed with high-sugar or high-fat diets for 12 months; after that, fasting glucose and insulin levels were measured along with a glucose tolerance test (GTT). Proteins related to insulin synthesis and secretion were quantified in pancreas homogenates, whereas islets were isolated to analyze ROS generation and size measurement. Our results show that both diets induce metabolic syndrome, linked with central obesity, hyperglycemia, and insulin resistance. We observed alterations in the expression of proteins related with insulin synthesis and secretion, along with diminution of Langerhans islets size. Interestingly, the severity and number of alterations were more evident in the high-sugar diet than in the high-fat diet group. In conclusion, obesity and glucose metabolism dysregulation induced by carbohydrate consumption, led to worst outcomes than high-fat diet.
(© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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