Outdoor clinical testing with reference sunscreens to determine differences in skin response between populations of different ethnicity: A combined data analysis from 128 subjects.

Autor: Granger C; Stella Polaris Europe, Paris, France., Passeron T; Department of Dermatology, CHU Nice, Côte d'Azur University, Nice, France.; C3M, INSERM U1065, Côte d'Azur University, Nice, France., Trullas C; Innovation and Development, ISDIN, Barcelona, Spain., Hosenally M; Centre International de Développement Pharmaceutique (CIDP), Phoenix, Mauritius.; Department of Economics and Statistics, University of Mauritius, Réduit, Mauritius., Sokeechand BN; Centre International de Développement Pharmaceutique (CIDP), Phoenix, Mauritius., Krutmann J; IUF Leibniz Research Institute for Environmental Medicine, Düsseldorf, Germany.; Medical Faculty, Heinrich Heine University, Düsseldorf, Germany., Lim HW; Photomedicine and Photobiology Unit, Department of Dermatology, Henry Ford Health System, Detroit, MI, USA.
Jazyk: angličtina
Zdroj: Photodermatology, photoimmunology & photomedicine [Photodermatol Photoimmunol Photomed] 2023 Sep; Vol. 39 (5), pp. 419-427. Date of Electronic Publication: 2023 Mar 13.
DOI: 10.1111/phpp.12871
Abstrakt: Background: Two previously published clinical studies by our group assessed erythema and pigmentation responses in outdoor conditions with three reference sunscreens, comparing their effectiveness under the full spectrum of natural sunlight. These studies followed an almost identical protocol but were conducted in two different locations and in two ethnic groups: broadly, Chinese (Singapore) and White European (Mauritius). We analysed the data from these two study populations to compare differences in skin response according to ethnicity.
Methods: The analysis included 128 subjects (53 were Chinese from Singapore and 75 were White European from Mauritius and Singapore). Products used were the reference sunscreens P3 (sun protection factor [SPF] 15), P5 (SPF 30) and P8 (SPF 50+) from ISO norm 24444:2019. Participants were exposed to outdoor sunlight for 2-3 h, depending on baseline ITA. Endpoints were erythema at 24 h: clinical score and colorimetry (Δa*) and pigmentation at 1 week based on colorimetry (ΔL* and ΔITA).
Results: Among those with baseline ITA > 41, there were differences in erythemal response between the Chinese and White European groups, the White European group being more erythematous and also having a higher rate of photoprotection failure particularly at SPFs 15 and 30.
Conclusion: Differences in skin response to sun influenced by ethnicity should be taken into account when making recommendations on sun safety.
(© 2023 John Wiley & Sons Ltd.)
Databáze: MEDLINE
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