Division of loading time in reloading the disused atrophic soleus muscle induces proximal muscle injury.
| Autor: | Miyachi R; Faculty of Health and Medical Sciences, Hokuriku University: 1-1 Taiyogaoka, Kanazawa, Ishikawa 920-1180, Japan., Morita Y; Department of Rehabilitation, Tokyo Medical and Dental University Hospital, Japan., Yamazaki T; Faculty of Health Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Japan. |
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| Jazyk: | angličtina |
| Zdroj: | Journal of physical therapy science [J Phys Ther Sci] 2023 Mar; Vol. 35 (3), pp. 193-198. Date of Electronic Publication: 2023 Mar 01. |
| DOI: | 10.1589/jpts.35.193 |
| Abstrakt: | [Purpose] This study aimed to compare the effects of loading time division in reloading atrophied muscles in different muscle long-axis regions. [Materials and Methods] We divided 8-week-old male Wistar rats into control (CON), 14-day hindlimb suspension (HS), 7-day hindlimb suspension followed by 60-min reloading for 7 consecutive days (WO), and 7-day hindlimb suspension followed by 60-min reloading on two separate occasions for 7 days (WT) groups. After the experimental period, muscle fibre cross-sectional area and necrotic fibre/central nuclei fibre ratio were measured in the soleus muscle's proximal, middle, and distal regions. [Results] The necrotic fibre/central nuclei fibre ratio was higher in the WT group than in the other groups in the proximal region. Proximal muscle fibre cross-sectional area was higher in the CON group than in the other groups. In the middle region, only HS group had muscle fibre cross-sectional area lower than the CON group. Similarly, muscle fibre cross-sectional area of the HS group was lower than the CON and WT groups in the distal region. [Conclusion] When reloading atrophied muscles, dividing the loading time can inhibit atrophy in the distal region but induce muscle injury in the proximal region. Competing Interests: The authors certify that there is no conflict of interest with any financial organization regarding the material discussed in the manuscript. (2023©by the Society of Physical Therapy Science. Published by IPEC Inc.) |
| Databáze: | MEDLINE |
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