| Autor: |
Pujol A; ISGlobal, Barcelona Center for International Health Research (CRESIB), Hospital Clínic - Universitat de Barcelona / Centro de Investigação em Saúde da Manhiça., Brokhattingen N; ISGlobal., Matambisso G; Manhiça Health research Center., Mbeve H; CISM., Cisteró P; ISGlobal., Escoda A; ISGlobal., Maculuve S; CISM., Cuna B; CISM., Melembe C; CISM., Ndimande N; CISM., Munguambe H; CISM., Lopez JM; Barcelona Institute for Global Health., Nhamussa L; Manhiça Health research Center., Simone W; Manhiça Health research Center., Tetteh K; London School of Hygiene & Tropical Medicine., Drakeley C; London School of Hygiene and Tropical Medicine, United Kingdom., Gamain B; INSERM., Chitnis C; Institut Pasteur., Chauhan VS; International Centre for Genetic Engineering & Biotechnology., Quintó L; Barcelona Institute for Global Health (ISGlobal)., Chidimatembue A; Manhiça Health research Center., Soler HM; ISGlobal Barcelona Institute for Global Health., Galatas B; ISGlobal, Barcelona Center for International Health Research (CRESIB), Hospital Clínic - Universitat de Barcelona / Centro de Investigação em Saúde da Manhiça., Guinovart C; ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona., Saute F; Centro de Investigação em Saúde de Manhiça., Aide P; Manhiça Health Research Centre., Macete E; Manhiça Health Research Center., Mayor A; ISGlobal, Barcelona Center for International Health Research (CRESIB), Hospital Clínic - Universitat de Barcelona / Centro de Investigação em Saúde da Manhiça. |
| Abstrakt: |
Pregnant women attending first antenatal care (ANC) visits represent a promising malaria surveillance target in Sub-Saharan Africa. Here we assessed the spatio-temporal relationship between malaria at ANC (n=6,471), in children at the community(n=9,362) and at health facilities (n=15,467) in southern Mozambique (2016-2019). ANC P. falciparum rates detected by quantitative polymerase chain reaction mirrored rates in children, regardless of gravidity and HIV status (Pearson correlation coefficient [PCC]>0.8, χ²<1.1), with a 2-3 months lag. Only at rapid diagnostic test detection limits at moderate-to-high transmission, multigravidae showed lower rates than children (PCC=0.61, 95%CI[-0.12-0.94]). Seroprevalence against the pregnancy-specific antigen VAR2CSA reflected declining malaria trends (PCC=0.74, 95%CI[0.24-0.77]). 80% (12/15) of hotspots detected from health facility data using a novel hotspot detector, EpiFRIenDs, were also identified with ANC data. The results show that ANC-based malaria surveillance offers contemporary information on temporal trends and the geographic distribution of malaria burden in the community. |
