Stimulating olfactory epithelium mitigates mechanical ventilation-induced hippocampal inflammation and apoptosis.

Autor: Ghazvineh S; Department of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran., Salimi M; Department of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran., Dehghan S; Stem Cell and Regenerative Medicine Research Center, Iran University of Medical Sciences, Tehran, Iran.; Eye Research Center, The Five Senses Institute, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran., Asemi-Rad A; Department of Anatomy, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran., Dehdar K; Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Salimi A; Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Jamaati H; Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Raoufy MR; Department of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.; Faculty of Medical Sciences, Institute for Brain Sciences and Cognition, Tarbiat Modares University, Tehran, Iran.
Jazyk: angličtina
Zdroj: Hippocampus [Hippocampus] 2023 Jul; Vol. 33 (7), pp. 880-885. Date of Electronic Publication: 2023 Mar 02.
DOI: 10.1002/hipo.23523
Abstrakt: Mechanical ventilation (MV), as a life-saving procedure in critical patients, is a risk factor to develop of neurocognitive dysfunction and triggers of inflammation and apoptosis in the brain. Since diversion of breathing route to the tracheal tube diminishes brain activity entrained by physiological nasal breathing, we hypothesized that simulating nasal breathing using rhythmic air-puff (AP) into the nasal cavity of mechanically ventilated rats can reduce hippocampal inflammation and apoptosis in association with restoring respiration-coupled oscillations. We found that stimulating olfactory epithelium through applying rhythmic nasal AP, in association with reviving respiration-coupled brain rhythm, mitigates MV-induced hippocampal apoptosis and inflammation involving microglia and astrocytes. The current translational study opens a window for a novel therapeutic approach to reduce neurological complications induced by MV.
(© 2023 Wiley Periodicals LLC.)
Databáze: MEDLINE
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