Associations of alternative cannabis product use and poly-use with subsequent illicit drug use initiation during adolescence.

Autor:	Braymiller JL; Department of Population and Public Health Sciences, University of Southern California, Keck School of Medicine, Los Angeles, CA, 90033, USA., Riehm KE; Department of Mental Health, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD, 21205, USA., Meier M; Department of Psychology, Arizona State University, Tempe, AZ, 85281, USA., Krueger EA; Department of Population and Public Health Sciences, University of Southern California, Keck School of Medicine, Los Angeles, CA, 90033, USA., Unger JB; Department of Population and Public Health Sciences, University of Southern California, Keck School of Medicine, Los Angeles, CA, 90033, USA., Barrington-Trimis JL; Department of Population and Public Health Sciences, University of Southern California, Keck School of Medicine, Los Angeles, CA, 90033, USA.; Institute for Addiction Science, University of Southern California, 2001 N Soto Street, #302-C, Los Angeles, CA, 90032, USA.; USC Norris Comprehensive Cancer Center, Los Angeles, CA, 90033, USA., Cho J; Department of Population and Public Health Sciences, University of Southern California, Keck School of Medicine, Los Angeles, CA, 90033, USA.; Institute for Addiction Science, University of Southern California, 2001 N Soto Street, #302-C, Los Angeles, CA, 90032, USA., Lanza HI; Department of Human Development, California State University, Long Beach, CA, 90840, USA., Madden DR; Institute for Addiction Science, University of Southern California, 2001 N Soto Street, #302-C, Los Angeles, CA, 90032, USA.; USC Suzanne Dworak-Peck School of Social Work, University of Southern California, Los Angeles, CA, 90089, USA., Kechter A; Department of Population and Public Health Sciences, University of Southern California, Keck School of Medicine, Los Angeles, CA, 90033, USA., Leventhal AM; Department of Population and Public Health Sciences, University of Southern California, Keck School of Medicine, Los Angeles, CA, 90033, USA. adam.leventhal@usc.edu.; Institute for Addiction Science, University of Southern California, 2001 N Soto Street, #302-C, Los Angeles, CA, 90032, USA. adam.leventhal@usc.edu.; USC Norris Comprehensive Cancer Center, Los Angeles, CA, 90033, USA. adam.leventhal@usc.edu.; Department of Psychology, University of Southern California, Los Angeles, CA, 90033, USA. adam.leventhal@usc.edu.
Jazyk:	angličtina
Zdroj:	Psychopharmacology [Psychopharmacology (Berl)] 2023 Mar 03. Date of Electronic Publication: 2023 Mar 03.
DOI:	10.1007/s00213-023-06330-w
Abstrakt:	Rationale: Specific cannabis products may differentially increase risk of initiating non-cannabis illicit drug use during adolescence. Objective: To determine whether ever- and poly-use of smoked, vaporized, edible, concentrate, or blunt cannabis products are associated with subsequent initiation of non-cannabis illicit drug use. Methods: High school students from Los Angeles completed in-classroom surveys. The analytic sample (N = 2163; 53.9% female; 43.5% Hispanic/Latino; baseline M age = 17.1 years) included students who reported never using illicit drugs at baseline (spring, 11th grade) and provided data at follow-up (fall and spring, 12th grade). Logistic regression models assessed associations between use of smoked, vaporized, edible, concentrate, and blunt cannabis at baseline (yes/no for each product) and any non-cannabis illicit drug use initiation-including cocaine, methamphetamine, psychedelics, ecstasy, heroin, prescription opioids, or benzodiazepines-at follow-up. Results: Among those who never used non-cannabis illicit drugs at baseline, ever cannabis use varied by cannabis product (smoked = 25.8%, edible = 17.5%, vaporized = 8.4%, concentrates = 3.9%, and blunts = 18.2%) and patterns of use (single product use = 8.2% and poly-product use = 21.8%). After adjustment for baseline covariates, odds of illicit drug use at follow-up were largest for baseline ever users of concentrates (aOR [95% CI] = 5.74[3.16-10.43]), followed by vaporized (aOR [95% CI] = 3.11 [2.41-4.01]), edibles (aOR [95% CI] = 3.43 [2.32-5.08]), blunts (aOR [95% CI] = 2.66[1.60-4.41]), and smoked (aOR [95% CI] = 2.57 [1.64-4.02]) cannabis. Ever use of a single product (aOR [95% CI] = 2.34 [1.26-4.34]) or 2 + products (aOR [95% CI] = 3.82 [2.73-5.35]) were also associated with greater odds of illicit drug initiation. Conclusions: For each of five different cannabis products, cannabis use was associated with greater odds of subsequent illicit drug use initiation, especially for cannabis concentrate and poly-product use. (© 2023. The Author(s).)
Databáze:	MEDLINE
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