Predicting anterior cruciate ligament failure load with T 2 * relaxometry and machine learning as a prospective imaging biomarker for revision surgery.

Autor: Flannery SW; Department of Orthopaedics, Warren Alpert Medical School of Brown University/Rhode Island Hospital, Coro West, Suite 402, 1 Hoppin St, Providence, RI, 02903, USA., Beveridge JE; Department of Orthopaedics, Warren Alpert Medical School of Brown University/Rhode Island Hospital, Coro West, Suite 402, 1 Hoppin St, Providence, RI, 02903, USA., Proffen BL; Division of Sports Medicine, Department of Orthopaedic Surgery, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA., Walsh EG; Department of Neuroscience, Division of Biology and Medicine, Brown University, Providence, RI, USA., Kramer DE; Division of Sports Medicine, Department of Orthopaedic Surgery, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA., Murray MM; Division of Sports Medicine, Department of Orthopaedic Surgery, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA., Kiapour AM; Division of Sports Medicine, Department of Orthopaedic Surgery, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA., Fleming BC; Department of Orthopaedics, Warren Alpert Medical School of Brown University/Rhode Island Hospital, Coro West, Suite 402, 1 Hoppin St, Providence, RI, 02903, USA. braden_fleming@brown.edu.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2023 Mar 02; Vol. 13 (1), pp. 3524. Date of Electronic Publication: 2023 Mar 02.
DOI: 10.1038/s41598-023-30637-5
Abstrakt: Non-invasive methods to document healing anterior cruciate ligament (ACL) structural properties could potentially identify patients at risk for revision surgery. The objective was to evaluate machine learning models to predict ACL failure load from magnetic resonance images (MRI) and to determine if those predictions were related to revision surgery incidence. It was hypothesized that the optimal model would demonstrate a lower mean absolute error (MAE) than the benchmark linear regression model, and that patients with a lower estimated failure load would have higher revision incidence 2 years post-surgery. Support vector machine, random forest, AdaBoost, XGBoost, and linear regression models were trained using MRI T 2 * relaxometry and ACL tensile testing data from minipigs (n = 65). The lowest MAE model was used to estimate ACL failure load for surgical patients at 9 months post-surgery (n = 46) and dichotomized into low and high score groups via Youden's J statistic to compare revision incidence. Significance was set at alpha = 0.05. The random forest model decreased the failure load MAE by 55% (Wilcoxon signed-rank test: p = 0.01) versus the benchmark. The low score group had a higher revision incidence (21% vs. 5%; Chi-square test: p = 0.09). ACL structural property estimates via MRI may provide a biomarker for clinical decision making.
(© 2023. The Author(s).)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje