Plant-based diets and the risk of pancreatic cancer: a large prospective multicenter study.
| Autor: | Zhong GC; Department of Hepatobiliary Surgery, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China. Electronic address: gczhong1991@hospital.cqmu.edu.cn., Li Z; Department of Breast and Thyroid Surgery, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China., You AJ; The Second Student Office, the Second College of Clinical Medicine, Chongqing Medical University, Chongqing, China., Zhu Q; Department of Nutrition and Food Hygiene, School of Public Health and Management, Chongqing Medical University, Chongqing, China., Wang CR; Department of Infectious Diseases, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China., Yang PF; Department of Nephrology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China. |
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| Jazyk: | angličtina |
| Zdroj: | The American journal of clinical nutrition [Am J Clin Nutr] 2023 Feb; Vol. 117 (2), pp. 235-242. |
| DOI: | 10.1016/j.ajcnut.2022.11.013 |
| Abstrakt: | Background: Plant-based diets have been recommended for improving health outcomes, including cancer. However, previous studies on plant-based diets and the risk of pancreatic cancer are scarce and fail to consider plant food quality. Objectives: We sought to examine the potential associations of 3 plant-based diet indices (PDIs) with the risk of pancreatic cancer in a US population. Methods: A population-based cohort of 101,748 US adults was identified from the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. The overall PDI, healthful PDI (hPDI), and unhealthful PDI (uPDI) were constructed to qualify adherence to overall, healthy, and less healthy plant-based diets, respectively, with higher scores indicating better adherence. Multivariable Cox regression was used to compute hazard ratios (HRs) for pancreatic cancer incidence. Subgroup analysis was conducted to identify the potential effect modifiers. Results: Over a mean follow-up of 8.86 years, 421 pancreatic cancer cases occurred. Participants in the highest compared with the lowest quartiles of overall PDI had a lower risk of pancreatic cancer [HR Conclusions: In this US population, adherence to a healthy plant-based diet confers a lower risk of pancreatic cancer, whereas adherence to a less healthy plant-based diet confers a higher risk. These findings highlight the importance of considering plant food quality in preventing pancreatic cancer. (Copyright © 2022 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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