Epigenetic regulation during 1,25-dihydroxyvitamin D 3 -dependent gene transcription.

Autor: Moena D; School of Bachelor in Science, Faculty of Life Sciences, Universidad Andres Bello, Concepcion, Chile., Vargas E; School of Medicine, Universidad Andres Bello, Santiago, Chile., Montecino M; Institute of Biomedical Sciences, Faculty of Medicine, Universidad Andres Bello, Santiago, Chile; Millenium Institute Center for Genome Regulation (CRG), Santiago, Chile. Electronic address: mmontecino@unab.cl.
Jazyk: angličtina
Zdroj: Vitamins and hormones [Vitam Horm] 2023; Vol. 122, pp. 51-74. Date of Electronic Publication: 2023 Feb 08.
DOI: 10.1016/bs.vh.2023.01.005
Abstrakt: Multiple evidence accumulated over the years, demonstrates that vitamin D-dependent physiological control in vertebrates occurs primarily through the regulation of target gene transcription. In addition, there has been an increasing appreciation of the role of the chromatin organization of the genome on the ability of the active form of vitamin D, 1,25(OH) 2 D 3 , and its specific receptor VDR to regulate gene expression. Chromatin structure in eukaryotic cells is principally modulated through epigenetic mechanisms including, but not limited to, a wide number of post-translational modifications of histone proteins and ATP-dependent chromatin remodelers, which are operative in different tissues during response to physiological cues. Hence, there is necessity to understand in depth the epigenetic control mechanisms that operate during 1,25(OH) 2 D 3 -dependent gene regulation. This chapter provides a general overview about epigenetic mechanisms functioning in mammalian cells and discusses how some of these mechanisms represent important components during transcriptional regulation of the model gene system CYP24A1 in response to 1,25(OH) 2 D 3 .
(Copyright © 2023 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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