Antibody Responses to the SARS-CoV-2 Ancestral Strain and Omicron Variants in Moderna mRNA-1273 Vaccinated Active-Duty US Navy Sailors and Marines.

Autor:	Sun P; Naval Medical Research Center, Silver Spring, Maryland, USA., Balinsky CA; Naval Medical Research Center, Silver Spring, Maryland, USA.; Henry Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA., Jiang L; Naval Medical Research Center, Silver Spring, Maryland, USA.; Henry Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA., Jani V; Naval Medical Research Center, Silver Spring, Maryland, USA.; Henry Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA., Long TK; Vysnova Partners, Inc, Landover, Maryland, USA., Cheng Y; Naval Medical Research Center, Silver Spring, Maryland, USA.; Leidos, Reston, Virginia, USA., Serote MA; Vysnova Partners, Inc, Landover, Maryland, USA., Smith AB; Third Marine Logistics Group, Okinawa, Japan., Fears BF; Third Marine Logistics Group, Okinawa, Japan., Gatrell SK; Naval Medical Research Center, Silver Spring, Maryland, USA.; Leidos, Reston, Virginia, USA., Sugiharto VA; Naval Medical Research Center, Silver Spring, Maryland, USA.; Henry Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA., Chen H; Naval Medical Research Center, Silver Spring, Maryland, USA.; Henry Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA., Zhang Z; Naval Medical Research Center, Silver Spring, Maryland, USA.; Henry Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA., Belinskaya T; Naval Medical Research Center, Silver Spring, Maryland, USA.; Henry Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA., Qiu Q; Naval Medical Research Center, Silver Spring, Maryland, USA.; Henry Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA., Graham WD; Naval Medical Research Center, Silver Spring, Maryland, USA., Schilling MA; Naval Medical Research Center, Silver Spring, Maryland, USA., Jones AR; Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand., Corson KS; US Naval Medical Research Unit TWO, Singapore, Singapore., Martin NJ; US Naval Medical Research Unit TWO, Singapore, Singapore., Letizia AG; US Naval Medical Research Unit TWO, Singapore, Singapore., Hontz RD; US Naval Medical Research Unit TWO, Singapore, Singapore.
Jazyk:	angličtina
Zdroj:	The Journal of infectious diseases [J Infect Dis] 2023 Jul 14; Vol. 228 (2), pp. 149-159.
DOI:	10.1093/infdis/jiad054
Abstrakt:	Omicron and its subvariants have steadily gained greater capability of immune escape compared to other variants of concern, resulting in an increased incidence of reinfections even among vaccinated individuals. We evaluated the antibody response to Omicron BA.1, BA.2, and BA.4/5 in US military members vaccinated with the primary 2-dose series of Moderna mRNA-1273 in a cross-sectional study. While nearly all vaccinated participants had sustained spike (S) IgG and neutralizing antibodies (ND50) to the ancestral strain, only 7.7% participants had detectable ND50 to Omicron BA.1 at 8 months postvaccination. The neutralizing antibody response to BA.2 and BA.5 was similarly reduced. The reduced antibody neutralization of Omicron correlated with the decreased antibody binding to the receptor-binding domain. The participants' seropositivity to the nuclear protein positively correlated with ND50. Our data emphasizes the need for continuous vigilance in monitoring for emerging variants and the need to identify potential alternative targets for vaccine design. Competing Interests: Potential conflicts of interest. All authors: No reported conflicts of interest. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed. (© The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
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