Free-breathing, Contrast Agent-free Whole-Heart MTC-BOOST Imaging: Single-Center Validation Study in Adult Congenital Heart Disease.

Autor:	Fotaki A; Department of Biomedical Engineering, School of Biomedical Engineering and Imaging Sciences, King's College London, St Thomas' Hospital, Westminster Bridge Road, Lambeth Wing, 3rd Floor, London SE1 7EH, England (A. Fotaki, K.P., R.H., A.S., J.F., R.N., K.P.K., A. Frigiola, R.M.B., C.P.); Department of MRI in Congenital Heart Disease, Guy's and St Thomas' NHS Foundation Trust, London, England (K.P., H.A., A. Frigiola); MR Research Collaborations, Siemens Healthcare Limited, Frimley, England (R.N., K.P.K.); and School of Engineering and Millennium Institute for Intelligent Healthcare Engineering, Pontificia Universidad Católica de Chile, Santiago, Chile (R.M.B., C.P.)., Pushparajah K; Department of Biomedical Engineering, School of Biomedical Engineering and Imaging Sciences, King's College London, St Thomas' Hospital, Westminster Bridge Road, Lambeth Wing, 3rd Floor, London SE1 7EH, England (A. Fotaki, K.P., R.H., A.S., J.F., R.N., K.P.K., A. Frigiola, R.M.B., C.P.); Department of MRI in Congenital Heart Disease, Guy's and St Thomas' NHS Foundation Trust, London, England (K.P., H.A., A. Frigiola); MR Research Collaborations, Siemens Healthcare Limited, Frimley, England (R.N., K.P.K.); and School of Engineering and Millennium Institute for Intelligent Healthcare Engineering, Pontificia Universidad Católica de Chile, Santiago, Chile (R.M.B., C.P.)., Hajhosseiny R; Department of Biomedical Engineering, School of Biomedical Engineering and Imaging Sciences, King's College London, St Thomas' Hospital, Westminster Bridge Road, Lambeth Wing, 3rd Floor, London SE1 7EH, England (A. Fotaki, K.P., R.H., A.S., J.F., R.N., K.P.K., A. Frigiola, R.M.B., C.P.); Department of MRI in Congenital Heart Disease, Guy's and St Thomas' NHS Foundation Trust, London, England (K.P., H.A., A. Frigiola); MR Research Collaborations, Siemens Healthcare Limited, Frimley, England (R.N., K.P.K.); and School of Engineering and Millennium Institute for Intelligent Healthcare Engineering, Pontificia Universidad Católica de Chile, Santiago, Chile (R.M.B., C.P.)., Schneider A; Department of Biomedical Engineering, School of Biomedical Engineering and Imaging Sciences, King's College London, St Thomas' Hospital, Westminster Bridge Road, Lambeth Wing, 3rd Floor, London SE1 7EH, England (A. Fotaki, K.P., R.H., A.S., J.F., R.N., K.P.K., A. Frigiola, R.M.B., C.P.); Department of MRI in Congenital Heart Disease, Guy's and St Thomas' NHS Foundation Trust, London, England (K.P., H.A., A. Frigiola); MR Research Collaborations, Siemens Healthcare Limited, Frimley, England (R.N., K.P.K.); and School of Engineering and Millennium Institute for Intelligent Healthcare Engineering, Pontificia Universidad Católica de Chile, Santiago, Chile (R.M.B., C.P.)., Alam H; Department of Biomedical Engineering, School of Biomedical Engineering and Imaging Sciences, King's College London, St Thomas' Hospital, Westminster Bridge Road, Lambeth Wing, 3rd Floor, London SE1 7EH, England (A. Fotaki, K.P., R.H., A.S., J.F., R.N., K.P.K., A. Frigiola, R.M.B., C.P.); Department of MRI in Congenital Heart Disease, Guy's and St Thomas' NHS Foundation Trust, London, England (K.P., H.A., A. Frigiola); MR Research Collaborations, Siemens Healthcare Limited, Frimley, England (R.N., K.P.K.); and School of Engineering and Millennium Institute for Intelligent Healthcare Engineering, Pontificia Universidad Católica de Chile, Santiago, Chile (R.M.B., C.P.)., Ferreira J; Department of Biomedical Engineering, School of Biomedical Engineering and Imaging Sciences, King's College London, St Thomas' Hospital, Westminster Bridge Road, Lambeth Wing, 3rd Floor, London SE1 7EH, England (A. Fotaki, K.P., R.H., A.S., J.F., R.N., K.P.K., A. Frigiola, R.M.B., C.P.); Department of MRI in Congenital Heart Disease, Guy's and St Thomas' NHS Foundation Trust, London, England (K.P., H.A., A. Frigiola); MR Research Collaborations, Siemens Healthcare Limited, Frimley, England (R.N., K.P.K.); and School of Engineering and Millennium Institute for Intelligent Healthcare Engineering, Pontificia Universidad Católica de Chile, Santiago, Chile (R.M.B., C.P.)., Neji R; Department of Biomedical Engineering, School of Biomedical Engineering and Imaging Sciences, King's College London, St Thomas' Hospital, Westminster Bridge Road, Lambeth Wing, 3rd Floor, London SE1 7EH, England (A. Fotaki, K.P., R.H., A.S., J.F., R.N., K.P.K., A. Frigiola, R.M.B., C.P.); Department of MRI in Congenital Heart Disease, Guy's and St Thomas' NHS Foundation Trust, London, England (K.P., H.A., A. Frigiola); MR Research Collaborations, Siemens Healthcare Limited, Frimley, England (R.N., K.P.K.); and School of Engineering and Millennium Institute for Intelligent Healthcare Engineering, Pontificia Universidad Católica de Chile, Santiago, Chile (R.M.B., C.P.)., Kunze KP; Department of Biomedical Engineering, School of Biomedical Engineering and Imaging Sciences, King's College London, St Thomas' Hospital, Westminster Bridge Road, Lambeth Wing, 3rd Floor, London SE1 7EH, England (A. Fotaki, K.P., R.H., A.S., J.F., R.N., K.P.K., A. Frigiola, R.M.B., C.P.); Department of MRI in Congenital Heart Disease, Guy's and St Thomas' NHS Foundation Trust, London, England (K.P., H.A., A. Frigiola); MR Research Collaborations, Siemens Healthcare Limited, Frimley, England (R.N., K.P.K.); and School of Engineering and Millennium Institute for Intelligent Healthcare Engineering, Pontificia Universidad Católica de Chile, Santiago, Chile (R.M.B., C.P.)., Frigiola A; Department of Biomedical Engineering, School of Biomedical Engineering and Imaging Sciences, King's College London, St Thomas' Hospital, Westminster Bridge Road, Lambeth Wing, 3rd Floor, London SE1 7EH, England (A. Fotaki, K.P., R.H., A.S., J.F., R.N., K.P.K., A. Frigiola, R.M.B., C.P.); Department of MRI in Congenital Heart Disease, Guy's and St Thomas' NHS Foundation Trust, London, England (K.P., H.A., A. Frigiola); MR Research Collaborations, Siemens Healthcare Limited, Frimley, England (R.N., K.P.K.); and School of Engineering and Millennium Institute for Intelligent Healthcare Engineering, Pontificia Universidad Católica de Chile, Santiago, Chile (R.M.B., C.P.)., Botnar RM; Department of Biomedical Engineering, School of Biomedical Engineering and Imaging Sciences, King's College London, St Thomas' Hospital, Westminster Bridge Road, Lambeth Wing, 3rd Floor, London SE1 7EH, England (A. Fotaki, K.P., R.H., A.S., J.F., R.N., K.P.K., A. Frigiola, R.M.B., C.P.); Department of MRI in Congenital Heart Disease, Guy's and St Thomas' NHS Foundation Trust, London, England (K.P., H.A., A. Frigiola); MR Research Collaborations, Siemens Healthcare Limited, Frimley, England (R.N., K.P.K.); and School of Engineering and Millennium Institute for Intelligent Healthcare Engineering, Pontificia Universidad Católica de Chile, Santiago, Chile (R.M.B., C.P.)., Prieto C; Department of Biomedical Engineering, School of Biomedical Engineering and Imaging Sciences, King's College London, St Thomas' Hospital, Westminster Bridge Road, Lambeth Wing, 3rd Floor, London SE1 7EH, England (A. Fotaki, K.P., R.H., A.S., J.F., R.N., K.P.K., A. Frigiola, R.M.B., C.P.); Department of MRI in Congenital Heart Disease, Guy's and St Thomas' NHS Foundation Trust, London, England (K.P., H.A., A. Frigiola); MR Research Collaborations, Siemens Healthcare Limited, Frimley, England (R.N., K.P.K.); and School of Engineering and Millennium Institute for Intelligent Healthcare Engineering, Pontificia Universidad Católica de Chile, Santiago, Chile (R.M.B., C.P.).
Jazyk:	angličtina
Zdroj:	Radiology. Cardiothoracic imaging [Radiol Cardiothorac Imaging] 2023 Feb 16; Vol. 5 (1), pp. e220146. Date of Electronic Publication: 2023 Feb 16 (Print Publication: 2023).
DOI:	10.1148/ryct.220146
Abstrakt:	Purpose: To assess the clinical performance of the three-dimensional, free-breathing, Magnetization Transfer Contrast Bright-and-black blOOd phase-SensiTive (MTC-BOOST) sequence in adult congenital heart disease (ACHD). Materials and Methods: In this prospective study, participants with ACHD undergoing cardiac MRI between July 2020 and March 2021 were scanned with the clinical T2-prepared balanced steady-state free precession sequence and proposed MTC-BOOST sequence. Four cardiologists scored their diagnostic confidence on a four-point Likert scale for sequential segmental analysis on images acquired with each sequence. Scan times and diagnostic confidence were compared using the Mann-Whitney test. Coaxial vascular dimensions at three anatomic landmarks were measured, and agreement between the research sequence and the corresponding clinical sequence was assessed with Bland-Altman analysis. Results: The study included 120 participants (mean age, 33 years ± 13 [SD]; 65 men). The mean acquisition time of the MTC-BOOST sequence was significantly lower compared with that of the conventional clinical sequence (9 minutes ± 2 vs 14 minutes ± 5; P < .001). Diagnostic confidence was higher for the MTC-BOOST sequence compared with the clinical sequence (mean, 3.9 ± 0.3 vs 3.4 ± 0.7; P < .001). Narrow limits of agreement and mean bias less than 0.08 cm were found between the research and clinical vascular measurements. Conclusion: The MTC-BOOST sequence provided efficient, high-quality, and contrast agent-free three-dimensional whole-heart imaging in ACHD, with shorter, more predictable acquisition time and improved diagnostic confidence compared with the reference standard clinical sequence. Keywords: MR Angiography, Cardiac Supplemental material is available for this article. Published under a CC BY 4.0 license. Competing Interests: Disclosures of conflicts of interest: A. Fotaki No relevant relationships. K.P. No relevant relationships. R.H. No relevant relationships. A.S. No relevant relationships. H.A. No relevant relationships. J.F. No relevant relationships. R.N. Employment contract with Siemens Healthcare; patent related to the technique used in the study (patent no. 20190064299); shareholder in Siemens Healthineers. K.P.K. Employee of Siemens Healthcare. A. Frigiola Provided study material, supervision, data analysis, and proofreading for this study; participation in regular governance meetings. R.M.B. Patent related to the technique used in the study (patent no. 20190064299). C.P. Patent related to the technique used in the study (patent no. 20190064299). (© 2023 by the Radiological Society of North America, Inc.)
Databáze:	MEDLINE
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