Minimally invasive surgery versus laparotomy in women with high risk endometrial cancer: A multi-center study performed in Argentina.

Autor:	Odetto D; Gynecology Oncology, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina., Rey Valzacchi GM; Department of Gynecologic Oncology, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina., Ostojich M; Department of Gynecology, Institute of Oncology Angel H. Roffo, University of Buenos Aires, Argentina., Alessandria S; Department of Gynecologic Oncology, Sanatorio Sagrado Corazón, Buenos Aires, Argentina., Darin MC; Department of Gynecology, Hospital Británico de Buenos Aires, Buenos Aires, Argentina., Tapper K; Center for Medical Education and Clinical Investigation (CEMIC), Buenos Aires, Argentina., Rita Amato A; Department of Gynecology, Complejo Médico Policial 'Churruca-Visca', Buenos Aires, Argentina., Luis Bianchi F; Department of Gynecology, Hospital Aleman de Buenos Aires, Buenos Aires, Argentina., Lopresti EF; Department of Gynecology, Hospital Central, Mendoza, Argentina., Cabrera LS; Department of Gynecology, Hospital Provincial Neuquén, Neuquén, Argentina., Costa J; Department of Gynecology, Hospital Privado de Rosario, Santa Fe, Argentina., Esteban A; Department of Gynecology, Sanatorio Allende, Córdoba, Argentina., Prozzillo L; Department of Gynecology, Hospital Español, Buenos Aires, Argentina., Escobar H; Department of Gynecology, Hospital Italiano Córdoba, Córdoba, Argentina., Bustos DG; Department of Gynecology, Hospital Privado de Córdoba, Córdoba, Argentina., Rosato OD; Department of Gynecology, Hospital Universitario de Maternidad y Neonatología de la Ciudad de Córdoba, Córdoba, Argentina., Picciochi RA; Department of Gynecology, Hospital José María Cullen, Santa Fe, Argentina., Garrido RM; Department of Gynecologic Oncology, Marie Curie, Buenos Aires, Argentina., de Degani GL; Department of Gynecology, Hospital San Martín, Paraná, Entre Ríos, Argentina., Vitale MSDV; Department of Gynecology.Hospital General de Agudos José María Penna, Buenos Aires, Argentina., Navarini RH; Department of Gynecology, Hospital Clemente Alvarez, Santa Fe, Argentina., Isnardi F; Department of Gynecology, Hospital Italiano Rosario, Santa Fe, Argentina., Franco G; Department of Gynecology, Hospital Nacional de Clínicas, Córdoba, Argentina., Rossini M; Department of Gynecology, Clínica del Niño y la Familia, Mar del Plata, Argentina., Carrizo MM; Department of Gynecology, Hospital Zonal Carlos Bocalandro, Buenos Aires, Argentina., Perrotta M; Department of Gynecologic Oncology, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina., Crimi G; Center for Medical Education and Clinical Investigation (CEMIC), Buenos Aires, Argentina.
Jazyk:	angličtina
Zdroj:	Gynecologic oncology reports [Gynecol Oncol Rep] 2023 Feb 10; Vol. 46, pp. 101147. Date of Electronic Publication: 2023 Feb 10 (Print Publication: 2023).
DOI:	10.1016/j.gore.2023.101147
Abstrakt:	Objective: Compare the perioperative outcomes and disease-free survival between minimally invasive and open surgery in women with stage I-II high-risk endometrial cancer. Methods: A retrospective, cohort study was performed involving twenty-four centers from Argentina. Patients with grade 3 endometrioid, serous, clear cell, undifferentiated carcinoma or carcinosarcoma who underwent hysterectomy, bilateral salpingo-oophorectomy, and staging between January 2010-2018 were included. Cox hazard regression analysis and Kaplan-Meier curves evaluated the association of surgical technique with survival. Results: Of 343 eligible patients, 214 (62 %) underwent open surgery and 129 (38 %) underwent laparoscopic surgery. No significant differences were seen between the two groups with respect to greater or equal grade III Clavien-Dindo postoperative complications (11 % in the open surgery group vs 9 % minimally invasive surgery group; P = 0.34) Minimally invasive surgery was not associated with worse disease-free survival at four years (79.14 % [95 % CI 69.42- 86.08] vs 78.80 % [95 % CI 70.61-84.96]), (p = 0.25), even after creating a Cox proportional model (hazard ratio [HR] 1.08 95 % CI 0.63-1.84); (p = 0.76). Conclusion: There was no difference between postoperative complications nor oncologic outcomes comparing minimally invasive and open surgery among patients with high-risk endometrial cancer. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2023 The Author(s).)
Databáze:	MEDLINE
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