In vivo characterization of microglia and myelin relation in multiple sclerosis by combined 11 C-PBR28 PET and synthetic MRI.

Autor: Barletta VT; Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 Thirteenth Street, Charlestown, Boston, MA, 02129, USA.; Harvard Medical School, Boston, MA, USA., Herranz E; Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 Thirteenth Street, Charlestown, Boston, MA, 02129, USA.; Harvard Medical School, Boston, MA, USA., Treaba CA; Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 Thirteenth Street, Charlestown, Boston, MA, 02129, USA.; Harvard Medical School, Boston, MA, USA., Mehndiratta A; Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 Thirteenth Street, Charlestown, Boston, MA, 02129, USA., Ouellette R; Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 Thirteenth Street, Charlestown, Boston, MA, 02129, USA.; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.; Department of Neuroradiology, Karolinska University Hospital, Stockholm, Sweden., Granberg T; Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 Thirteenth Street, Charlestown, Boston, MA, 02129, USA.; Harvard Medical School, Boston, MA, USA.; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.; Department of Neuroradiology, Karolinska University Hospital, Stockholm, Sweden., Klawiter EC; Harvard Medical School, Boston, MA, USA.; Department of Neurology, Massachusetts General Hospital, Boston, USA., Ionete C; UMass Memorial Medical Center, University Campus, Worcester, USA., Sloane JA; Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, USA., Mainero C; Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 Thirteenth Street, Charlestown, Boston, MA, 02129, USA. cmainero@mgh.harvard.edu.; Harvard Medical School, Boston, MA, USA. cmainero@mgh.harvard.edu.
Jazyk: angličtina
Zdroj: Journal of neurology [J Neurol] 2023 Jun; Vol. 270 (6), pp. 3091-3102. Date of Electronic Publication: 2023 Mar 02.
DOI: 10.1007/s00415-023-11621-5
Abstrakt: Background: The in vivo relation between microglia activation and demyelination in multiple sclerosis is still unclear.
Objective: We combined 11 C-PBR28 positron emission tomography and rapid estimation of myelin for diagnostic imaging (REMyDI) to characterize the relation between these pathological processes in a heterogeneous MS cohort.
Methods: 11 C-PBR28 standardized uptake values normalized by a pseudo-reference region (SUVR) were used to measure activated microglia. A voxelwise analysis compared 11 C-PBR28 SUVR in the white matter of 38 MS patients and 16 matched healthy controls. The relative difference in SUVR served as a threshold to classify patients' lesioned, perilesional and normal-appearing white matter as active or inactive. REMyDI was acquired in 27 MS patients for assessing myelin content in active and inactive white matter and its relationship with SUVR. Finally, we investigated the contribution of radiological metrics to clinical outcomes.
Results: 11 C-PBR28 SUVR were abnormally higher in several white matter areas in MS. Myelin content was lower in active compared to inactive corresponding white matter regions. An inverse correlation between SUVR and myelin content was found. Radiological metrics correlated with both neurological and cognitive impairment.
Conclusion: our data suggest an inverse relation of microglia activation and myelination, particularly in perilesional white matter tissue.
(© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany.)
Databáze: MEDLINE
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