Preliminary evaluation of haemostatic and wound healing potential of Heliotropium europaeum.

Autor: Moalla DR; Laboratory of Pharmacology, Faculty of Medicine of Sfax, University of Sfax, Majida Boulila Avenue, 3029, Sfax, Tunisia. rmdorsaf@gmail.com., Ben Khedir S; Laboratories of Histology and Embryology, Faculty of Medicine of Sfax, University of Sfax, Sfax, Tunisia., Amouri S; Laboratory of Pharmacology, Faculty of Medicine of Sfax, University of Sfax, Majida Boulila Avenue, 3029, Sfax, Tunisia., Jardak N; Laboratories of Histology and Embryology, Faculty of Medicine of Sfax, University of Sfax, Sfax, Tunisia., Rebai T; Laboratories of Histology and Embryology, Faculty of Medicine of Sfax, University of Sfax, Sfax, Tunisia., Sahnoun Z; Laboratory of Pharmacology, Faculty of Medicine of Sfax, University of Sfax, Majida Boulila Avenue, 3029, Sfax, Tunisia.
Jazyk: angličtina
Zdroj: Archives of dermatological research [Arch Dermatol Res] 2023 Sep; Vol. 315 (7), pp. 1945-1952. Date of Electronic Publication: 2023 Mar 01.
DOI: 10.1007/s00403-023-02572-y
Abstrakt: Heliotropium europaeum has been traditionally used to stop bleeding and accelerate scarring. This study provides a scientific evaluation of H. europaeum haemostatic and healing potential. To evaluate the haemostatic effect of H. europaeum, the time of bleeding of fresh wounds induced experimentally in rats was studied. Excision wounds were induced upon four groups; each one contains six rats to estimate the healing properties of wounds. Group 1 was assigned as control (not treated), group 2 was daily treated with H. europaeum leaf powder, group 3 was treated with H. europaeum every 6 days and group 4 was treated with a reference drug, an emulsion containing 10% of Mimosa tenuiflora extract. All the parameters were significantly tested (p < 0.05) with comparison to a group control. The use of H. europaeum significantly shortened the bleeding time. The rats which were daily treated with H. europaeum healed in 12 days. This time period was significantly shorter than the control groups. Wound excision was uniformly induced randomly on the dorsum of rats in 4 groups (tested support and control). The post-healing biopsies were histologically assessed, revealed a better healing quality, and continued complete tissue regeneration, abundant and well-organized network of collagen fibres, and low numbers of inflammatory cells. The experimental data revealed that H. europaeum displayed remarkable haemostatic and wound healing activities.
(© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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