Association between genetic variants in TREM1, CXCL10, IL4, CXCL8 and TLR7 genes with the occurrence of congenital Zika syndrome and severe microcephaly.

Autor: Santos CNO; Immunology and Molecular Biology Laboratory and Graduate Program in Health Sciences, University Hospital of Federal University of Sergipe, Aracaju, Brazil. camillanatallia@hotmail.com., Magalhães LS; Immunology and Molecular Biology Laboratory and Graduate Program in Health Sciences, University Hospital of Federal University of Sergipe, Aracaju, Brazil.; Sector of Parasitology and Pathology, Biological and Health Sciences Institute, Federal University of Alagoas, Maceió, Brazil., Fonseca ABL; Pediatric Division of University Hospital of the Federal University of Sergipe, Aracaju, Brazil., Bispo AJB; Pediatric Division of University Hospital of the Federal University of Sergipe, Aracaju, Brazil., Porto RLS; Pediatric Division of University Hospital of the Federal University of Sergipe, Aracaju, Brazil., Alves JC; Immunology and Molecular Biology Laboratory and Graduate Program in Health Sciences, University Hospital of Federal University of Sergipe, Aracaju, Brazil., Dos Santos CA; Central Public Health Laboratory of Sergipe, Health Foundation Parreiras Horta, Aracaju, Brazil., de Carvalho JV; Department of Medicine of University Hospital, Federal University of Sergipe, Aracaju, Brazil., da Silva AM; Immunology and Molecular Biology Laboratory and Graduate Program in Health Sciences, University Hospital of Federal University of Sergipe, Aracaju, Brazil.; Department of Medicine of University Hospital, Federal University of Sergipe, Aracaju, Brazil., Teixeira MM; Federal University of Minas Gerais, Belo Horizonte, Brazil., de Almeida RP; Immunology and Molecular Biology Laboratory and Graduate Program in Health Sciences, University Hospital of Federal University of Sergipe, Aracaju, Brazil.; Department of Medicine of University Hospital, Federal University of Sergipe, Aracaju, Brazil., Dos Santos PL; Immunology and Molecular Biology Laboratory and Graduate Program in Health Sciences, University Hospital of Federal University of Sergipe, Aracaju, Brazil., de Jesus AR; Immunology and Molecular Biology Laboratory and Graduate Program in Health Sciences, University Hospital of Federal University of Sergipe, Aracaju, Brazil.; Department of Medicine of University Hospital, Federal University of Sergipe, Aracaju, Brazil.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2023 Mar 01; Vol. 13 (1), pp. 3466. Date of Electronic Publication: 2023 Mar 01.
DOI: 10.1038/s41598-023-30342-3
Abstrakt: Congenital Zika syndrome (CZS) is a cluster of malformations induced by Zika virus (ZIKV) infection and the underline mechanisms involved in its occurrence are yet not fully understood. Along with epidemiological and environmental factors, the genetic host factors are suggested as important to the CZS occurrence and development, however, few studies have evaluated this. This study enrolled a total of 245 individuals in a case-control association study compound a cohort of high specific interest constituted by 75 mothers who had delivered CZS infants, their 76 infants, and 47 mothers that had delivered healthy infants, and their 47 infants. Sixteen single-nucleotide polymorphisms on TREM1, CXCL10, IL4, CXCL8, TLR3, TLR7, IFNR1, CXCR1, IL10, CCR2 and CCR5 genes were genotyped to investigate their association as risk factors to CZS. The results show an association between C allele at TREM1 rs2234246 and C allele at IL4 rs224325 in mothers infected with ZIKV during pregnancy, with the increased susceptibility to CZS occurrence in their infants and the SNP CXCL8 rs4073 and the G allele at CXCL10 rs4508917 with presence of CZS microcephaly in the infants. Furthermore, the T allele at CXCL8 rs4073 and TRL7 rs179008 SNPs were associated with the severity of microcephaly in children with CZS. These results suggest that these polymorphisms in genes of innate immune responses addressed here are associated to increased risk of occurrence and severity of CZS in pregnant mothers infected with ZIKV and their CZS infants.
(© 2023. The Author(s).)
Databáze: MEDLINE
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