Prevalence of orofacial alterations in patients with sickle-cell disease: Systematic review and meta-analysis.

Autor: da Costa TMP; Oral Radiology Division, São Leopoldo Mandic Research Institute, Campinas, São Paulo, Brazil., Nascimento MDCC; Oral Radiology Division, São Leopoldo Mandic Research Institute, Campinas, São Paulo, Brazil., Peralta-Mamani M; Department of Surgery, Stomatology, Pathology and Radiology, Bauru School of Dentistry, University of São Paulo, Bauru, Brazil., Rubira-Bullen IRF; Department of Surgery, Stomatology, Pathology and Radiology, Bauru School of Dentistry, University of São Paulo, Bauru, Brazil., Junqueira JLC; Oral Radiology Division, São Leopoldo Mandic Research Institute, Campinas, São Paulo, Brazil., Soares MQS; Oral Radiology Division, São Leopoldo Mandic Research Institute, Campinas, São Paulo, Brazil. Electronic address: mariana.soares@slmandic.edu.br.
Jazyk: angličtina
Zdroj: Oral surgery, oral medicine, oral pathology and oral radiology [Oral Surg Oral Med Oral Pathol Oral Radiol] 2023 May; Vol. 135 (5), pp. 642-660. Date of Electronic Publication: 2022 Dec 27.
DOI: 10.1016/j.oooo.2022.12.009
Abstrakt: Objective: The aim of this study was to identify the prevalence of orofacial alterations in sickle-cell disease (SCD) and to compare it with the general population.
Study Design: This review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 guidelines. The search was conducted on PubMed, Embase, Scientific Electronic Library Online, Web of Science, Cochrane Library, gray literature, and references of the included articles.
Results: A total of 770 records were found, and 28 studies were selected. In SCD, the prevalence of decreased bone density was 57% (95% CI: 35%-80%), with Q: P < .01 and I 2  = 95%; for stepladder pattern was 30% (IC: 13%-47%), Q: P < .01 and I²: 93%; for delayed eruption was 20% (95% CI: 6%-34%), with Q: P < .01 and I 2  = 86, Q: P < .01 and I 2  = 99%; and for malocclusion, 66% (95% CI: 39%-92%), Q: P < .01 and I 2  = 98%. A high risk of bias was observed in relation to the sample size of the studies. A limited number of articles compared the prevalence of orofacial alterations in patients with SCD and healthy individuals.
Conclusions: Decreased bone density, malocclusion, orofacial pain, tooth necrosis, eruption delay, periodontal disease, and neuropathies may be present in patients with SCD with variable prevalence.
Competing Interests: Declarations of interest None.
(Copyright © 2023 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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