Key cytokines and hematological parameters in patients with uncomplicated falciparum malaria in Hodeidah, Yemen.

Autor: Saleh AG; Faculty of Medicine and Health Sciences, Hodeidah University, Yemen., Shehab AY; Department of Parasitology, Medical Research Institute, University of Alexandria, Egypt., Abdul-Ghani R; Department of Medical Parasitology, Faculty of Medicine and Health Sciences, Sana'a University, Sana'a, Yemen and Tropical Disease Research Center, Faculty of Medicine and Health Sciences, University of Science and Technology, Sana'a, Yemen., Allam AF; Department of Parasitology, Medical Research Institute, University of Alexandria, Egypt., Osman MM; Department of Parasitology, Medical Research Institute, University of Alexandria, Egypt., Ibrahim HS; Department of Parasitology, Medical Research Institute, University of Alexandria, Egypt., El-Taweel HA; Department of Parasitology, Medical Research Institute, University of Alexandria, Egypt. Electronic address: hend.eltaweel@alexu.edu.eg., Moneer EA; Department of Medical Laboratory, Faculty of Applied Health Sciences Technology, Pharos University, Alexandria, Egypt., Hagras NA; Department of Medical Laboratory, Faculty of Applied Health Sciences Technology, Pharos University, Alexandria, Egypt., Farag HF; Department of Parasitology, Medical Research Institute, University of Alexandria, Egypt.
Jazyk: angličtina
Zdroj: Cytokine [Cytokine] 2023 Apr; Vol. 164, pp. 156156. Date of Electronic Publication: 2023 Feb 27.
DOI: 10.1016/j.cyto.2023.156156
Abstrakt: Immunity to malaria has a major role in controlling disease and pathogenesis with cytokine production being involved in almost every phase of the immune response. The present study aimed to assess hematological variables and to measure plasma levels of TNFα, IFNγ and IL10, their ratios, and their relation to parasitemia among patients with uncomplicated falciparum malaria in Hodeidah, Yemen. Forty patients with uncomplicated P. falciparum monoinfection and 40 healthy age and sex-matched controls were enrolled in the study. Parasitological diagnosis was confirmed, and parasite density was estimated. Plasma cytokine levels, hematologic parameters, and the presence of gametocytes were determined. Results revealed higher TNFα, IFNγ and IL10 in patients than in controls. A relatively higher IL10 production was demonstrated by the significantly lower TNFα/IL10 and IFNγ/IL10 ratios in patients than in controls. TNFα and IL10 correlated positively with parasite density. Lower Hb levels, RBC, lymphocyte and platelet counts, and higher neutrophil and reticulocyte counts were observed in patients compared to controls. Reticulocyte count was higher and IFNγ level was lower in the presence of gametocytes. Conclusively, uncomplicated falciparum malaria is associated with the ability to regulate the production of pro-inflammatory and anti-inflammatory cytokines. This mediates parasite clearance while simultaneously avoiding severe pathology.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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