Parental Obesity Predisposition and Age of Onset Associate with Poor Response to Bariatric and Metabolic Surgery.

Autor: Fink M; Department of General and Visceral Surgery, Medical Center Freiburg, University of Freiburg, Hugstetter Strasse 55, 79106, Freiburg, Germany., Herrmann S; Department of General and Visceral Surgery, Medical Center Freiburg, University of Freiburg, Hugstetter Strasse 55, 79106, Freiburg, Germany., Fink J; Department of General and Visceral Surgery, Medical Center Freiburg, University of Freiburg, Hugstetter Strasse 55, 79106, Freiburg, Germany., Lässle C; Department of General and Visceral Surgery, Medical Center Freiburg, University of Freiburg, Hugstetter Strasse 55, 79106, Freiburg, Germany., Marjanovic G; Department of General and Visceral Surgery, Medical Center Freiburg, University of Freiburg, Hugstetter Strasse 55, 79106, Freiburg, Germany., Fagnocchi L; Department of Epigenetics, Van Andel Institute, 333 Bostwick Ave NE, Grand Rapids, MI, 49503, USA., Pospisilik JA; Department of Epigenetics, Van Andel Institute, 333 Bostwick Ave NE, Grand Rapids, MI, 49503, USA., Fichtner-Feigl S; Department of General and Visceral Surgery, Medical Center Freiburg, University of Freiburg, Hugstetter Strasse 55, 79106, Freiburg, Germany., Seifert G; Department of General and Visceral Surgery, Medical Center Freiburg, University of Freiburg, Hugstetter Strasse 55, 79106, Freiburg, Germany. gabriel.seifert@uniklinik-freiburg.de.
Jazyk: angličtina
Zdroj: Obesity surgery [Obes Surg] 2023 May; Vol. 33 (5), pp. 1519-1527. Date of Electronic Publication: 2023 Mar 01.
DOI: 10.1007/s11695-023-06499-1
Abstrakt: Introduction: Parental predisposition and age of onset may be independently associated with 1-year total weight loss (TWL) failure (< 20%) after metabolic-bariatric surgery (MBS).
Methods: This cohort study includes all cases of the German StuDoQ|MBE register (2015-2019) with data on parental predisposition, obesity onset, and at least 1-year follow up after primary MBS procedures (n = 14,404). We provide descriptive statistics of the cohort in terms of the main outcome and 1-year TWL failure, and provide characteristics of surgery type subgroups. Finally, we provide a multivariate logistic regression model of 1-year TWL failure.
Results: 58.8% and 45.7% of patients reported maternal and paternal predisposition for obesity, respectively. Average onset of obesity was 15.5 years and duration of disease 28.3 years prior to MBS. SG is the most frequently performed procedure (47.2%) followed by RYGB (39.7%) and OAGB (13.1%). Mean 1-year TWL is 32.7 ± 9.3%, and 7.8% (n = 1,119) of patients show TWL failure (< 20%). Multivariate analysis shows independent association of early onset of obesity (< 18 years), male sex, age at operation, pre-operative BMI, pre-operative weight loss, sleeve gastrectomy (SG), and type 2 diabetes (T2D) with 1-year TWL failure (p < 0.001).
Conclusion: The proportions of MBS patients that report on paternal and maternal predisposition for obesity are 45.7% and 58.8% respectively, and average age at onset is 15.5 years. 7.8% of patients do not meet current target criteria of successful response to surgery at 1 year. Early onset, male sex, age at operation, pre-operative BMI, pre-operative weight loss, SG, and T2D are independently associated with weight loss failure.
(© 2023. The Author(s).)
Databáze: MEDLINE
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