A Novel Ubiquitin Complex Regulates Aneuploid Epithelial Tumors by Moderating an Integrated Stress Response.
| Autor: | Leli NM; Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania., Koumenis C; Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. |
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| Jazyk: | angličtina |
| Zdroj: | Cancer discovery [Cancer Discov] 2023 Mar 01; Vol. 13 (3), pp. 535-537. |
| DOI: | 10.1158/2159-8290.CD-22-1440 |
| Abstrakt: | Summary: Tumor fitness coessentiality gene analysis that aims to expand the repertoire of druggable targets reveals a novel ubiquitin ligase complex, the BICR6 module. Along with the other complex members (UBA6, KCMF1, and UBR4), BIRC6 selectively contributes to the survival of a subset of epithelial tumors with a high degree of aneuploidy by ubiquitinating and suppressing HRI, a component of the integrated stress response adaptive pathway. See related article by Cervia et al., p. 766 (2). (©2023 American Association for Cancer Research.) |
| Databáze: | MEDLINE |
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