| Autor: |
Ben Aïssa A; Service d'oncologie, Hôpitaux Universitaires de Genève, Geneva, Switzerland. |
| Jazyk: |
angličtina |
| Zdroj: |
Praxis [Praxis (Bern 1994)] 2023; Vol. 112 (3), pp. 135-142. |
| DOI: |
10.1024/1661-8157/a003972 |
| Abstrakt: |
Melanoma is the most aggressive skin cancer, and surgery is the standard of care for localised disease. However, a risk of local and distant relapse exists despite tumour removal, particularly with thick or ulcerated tumours or lymph node involvement. Immunotherapy with immune checkpoint inhibitors (ICIs) targeting PD-1, PD-L-1 or CTLA-4 demonstrated improved relapse-free survival and distant metastasis-free survival against placebo after surgery for stage-III and high-risk stage-II melanoma. In unresectable localised and metastatic tumours, the double immunotherapy with ICIs (anti-PD-1+ anti-CTLA-4) allows for long-term survival in more than 50% of the patients. Novel immunotherapies (anti-LAG-3 ICI, adoptive cell therapy, intra-tumoural immunotherapy, cancer vaccines) and new combinations are in development to overcome resistance and improve patients' survival. Therapeutic decisions for each patient should be discussed in a specialised multidisciplinary team. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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