The effect of autosomal dominant polycystic kidney disease on mucociliary clearance.

Autor: Kara İ; Department of Otorhinolaryngology, Medical Faculty, Kahramanmaraş Sutcu Imam University, Kahramanmaras, Turkey. drirfankara@gmail.com., Öztürk İ; Department of Nephrology, Faculty of Medicine, Kahramanmaraş Sutcu Imam University, Kahramanmaras, Turkey., Doğaner A; Department of Bioistatistics, Faculty of Medicine, Kahramanmaras Sutcu Imam University, Kahramanmaras, Turkey., Yıldız MG; Department of Otolaryngology, Faculty of Medicine, Kahramanmaraş Sutcu Imam University, Kahramanmaras, Turkey., Güzel FB; Department of Nephrology, Faculty of Medicine, Kahramanmaraş Sutcu Imam University, Kahramanmaras, Turkey., Kılıç A; Department of Otolaryngology, Faculty of Medicine, Kahramanmaraş Sutcu Imam University, Kahramanmaras, Turkey., Orhan İ; Department of Otolaryngology, Faculty of Medicine, Kahramanmaraş Sutcu Imam University, Kahramanmaras, Turkey., Altınören O; Department of Nephrology, Faculty of Medicine, Kahramanmaraş Sutcu Imam University, Kahramanmaras, Turkey.
Jazyk: angličtina
Zdroj: European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery [Eur Arch Otorhinolaryngol] 2023 May; Vol. 280 (5), pp. 2359-2364. Date of Electronic Publication: 2023 Feb 28.
DOI: 10.1007/s00405-023-07891-4
Abstrakt: Purpose: Autosomal dominant polycystic kidney disease (ADPKD) is a renal disease with genetic transmisson. Mutations in the PKD1 and PKD2 genes, which encode integral membrane proteins of the cilia of primary renal tubule epithelial cells, are seen in ADPKD. The aim of this study was to evaluate the sinonasal epithelium, which is epithelium with cilia, by measuring the nasal mucociliary clearance time, and to investigate the effect of ADPKD on nasal mucociliary clearance.
Methods: The study included 34 patients, selected from patients followed up in the Nephrology Clinic, and 34 age and gender-matched control group subjects. The nasal mucociliary clearance time (NMCT) was measured with the saccharin test.
Results: The mean age of the study subjects was 47.15 ± 14.16 years in the patient group and 47.65 ± 13.85 years in the control group. The eGFR rate was determined as mean 72.06 ± 34.26 mL/min in the patient group and 99.79 ± 17.22 mL/min in the control group (p < 0.001). The NMCT was determined to be statistically significantly longer in the patient group (903.6 ± 487.8 s) than in the control group (580 ± 259 s) (p = 0.006).
Conclusions: The study results showed that the NMCT was statistically significantly longer in patients with ADPKD compared to the control group, but in the linear regression analysis results, no correlation was determined between eGFR and NMCT.
(© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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