Lifespan differences in visual short-term memory load-modulated functional connectivity.

Autor: Lugtmeijer S; Department of Psychology, Brock University, 1812 Sir Isaac Brock Way, St. Catharines, ON L2S 3A1, Canada. Electronic address: slugtmeijer@brocku.ca., Geerligs L; Radboud University, Thomas van Aquinostraat 4, 6525 GD, Nijmegen, the Netherlands. Electronic address: linda.geerligs@donders.ru.nl., Tsvetanov KA; Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0QQ, United Kingdom; Department of Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom. Electronic address: kat35@cam.ac.uk., Mitchell DJ; MRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge CB2 7EF, United Kingdom. Electronic address: Daniel.Mitchell@mrc-cbu.cam.ac.uk., Cam-Can; Cambridge Centre for Ageing and Neuroscience (Cam-CAN), University of Cambridge and MRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge CB2 7EF, United Kingdom. Electronic address: ccmanagement@cam-can.com., Campbell KL; Department of Psychology, Brock University, 1812 Sir Isaac Brock Way, St. Catharines, ON L2S 3A1, Canada. Electronic address: Karen.Campbell@brocku.ca.
Jazyk: angličtina
Zdroj: NeuroImage [Neuroimage] 2023 Apr 15; Vol. 270, pp. 119982. Date of Electronic Publication: 2023 Feb 26.
DOI: 10.1016/j.neuroimage.2023.119982
Abstrakt: Working memory is critical to higher-order executive processes and declines throughout the adult lifespan. However, our understanding of the neural mechanisms underlying this decline is limited. Recent work suggests that functional connectivity between frontal control and posterior visual regions may be critical, but examinations of age differences therein have been limited to a small set of brain regions and extreme group designs (i.e., comparing young and older adults). In this study, we build on previous research by using a lifespan cohort and a whole-brain approach to investigate working memory load-modulated functional connectivity in relation to age and performance. The article reports on analysis of the Cambridge center for Ageing and Neuroscience (Cam-CAN) data. Participants from a population-based lifespan cohort (N = 101, age 23-86) performed a visual short-term memory task during functional magnetic resonance imaging. Visual short-term memory was measured with a delayed recall task for visual motion with three different loads. Whole-brain load-modulated functional connectivity was estimated using psychophysiological interactions in a hundred regions of interest, sorted into seven networks (Schaefer et al., 2018, Yeo et al., 2011). Results showed that load-modulated functional connectivity was strongest within the dorsal attention and visual networks during encoding and maintenance. With increasing age, load-modulated functional connectivity strength decreased throughout the cortex. Whole-brain analyses for the relation between connectivity and behavior were non-significant. Our results give additional support to the sensory recruitment model of working memory. We also demonstrate the widespread negative impact of age on the modulation of functional connectivity by working memory load. Older adults might already be close to ceiling in terms of their neural resources at the lowest load and therefore less able to further increase connectivity with increasing task demands.
Competing Interests: Declaration of Competing Interest The authors declare no conflict of interests. For the purpose of open access, the author has applied a Creative Commons Attribution (CC BY) licence to any Author Accepted Manuscript version arising from this submission.
(Copyright © 2023. Published by Elsevier Inc.)
Databáze: MEDLINE
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