The association between antihypertensive medications and mental health outcomes among Syrian war refugees with stress and hypertension.

Autor: Gammoh O; Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmacy, Yarmouk University, Irbid, Jordan. Electronic address: omar.gammoh@yu.edu.jo., Bjørk MH; Department of Clinical Medicine, University of Bergen, Bergen, Norway; Department of Neurology, Haukeland University Hospital, Bergen, Norway., Al Rob OA; Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmacy, Yarmouk University, Irbid, Jordan., AlQudah AR; Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmacy, The Hashemite University, Zarqa, Jordan., Hani AB; Cardiovascular Surgery & Intensive Care, General Surgery Department, School of Medicine, The University of Jordan, Queen Rania Str. Jordan, Amman, Jordan., Al-Smadi A; Faculty of Nursing, Al al-Bayt University, Mafraq, Jordan.
Jazyk: angličtina
Zdroj: Journal of psychosomatic research [J Psychosom Res] 2023 May; Vol. 168, pp. 111200. Date of Electronic Publication: 2023 Feb 20.
DOI: 10.1016/j.jpsychores.2023.111200
Abstrakt: Background: Little is known about the association between antihypertensive drugs with mental health outcomes. We examined the association between the antihypertensive classes and other clinical patient features with symptoms of depression, anxiety, insomnia, and Post-Traumatic Stress Disorder (PTSD) in a cohort of Syrian war refugees with stress and hypertension residing in Jordan.
Methods: This cross-sectional study recruited hypertensive Syrian refugees with stress. Depression severity was assessed using the Patient Health Questionnaire-9, anxiety was measured by The General Anxiety Disorder-7, the Insomnia Severity Index was used to evaluate sleep quality and PTSD was measured using Davidson Trauma Scale. To investigate the association between the different classes of antihypertensive medication and mental health outcomes we used multivariable regression models.
Results: Of the 492 participants, 251 were men (51%), 234 (47.6%) were on β-blockers, 141 (28.7%) on diuretics, and 209 (42.5%) on Angiotensin Converting Enzyme Inhibitors (ACEIs)/Angiotensin Receptor Blockers (ARBs). Although the multivariate regression revealed the different classes of antihypertensives are not associated with mental health symptoms, however, physical activity is associated with lower adjusted odds for symptoms of depression (0.68 (0.46-0.99), p = 0.04), anxiety (0.60 (0.42-0.85),p = 0.005), insomnia (0.63 (0.44-0.91),p = 0.01) and dyslipidemia (3.48(0.29-6.69),p = 0.03) is associated with higher PTSD symptoms.
Limitations: The study subjects were not assessed for psychiatric diagnoses clinically. Further, we used a cross-sectional design that does not allow to measure longitudinal changes.
Conclusions: The association between antihypertensive drugs and mental health symptoms was not evident in the present study. Follow-up future studies are required.
Competing Interests: Declaration of Competing Interest None
(Copyright © 2023 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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