An Antifibrotic Breast Implant Surface Coating Significantly Reduces Periprosthetic Capsule Formation.

Autor:	Karinja SJ; From the Laboratory of Bioregenerative Medicine & Surgery, Weill Cornell Medical College.; Department of Surgery, Division of Plastic Surgery., Bernstein JL; From the Laboratory of Bioregenerative Medicine & Surgery, Weill Cornell Medical College.; Department of Surgery, Division of Plastic Surgery., Mukherjee S; Department of Bioengineering, Rice University., Jin J; From the Laboratory of Bioregenerative Medicine & Surgery, Weill Cornell Medical College.; Department of Surgery, Division of Plastic Surgery., Lin A; From the Laboratory of Bioregenerative Medicine & Surgery, Weill Cornell Medical College.; Department of Surgery, Division of Plastic Surgery., Abadeer A; From the Laboratory of Bioregenerative Medicine & Surgery, Weill Cornell Medical College.; Department of Surgery, Division of Plastic Surgery., Kaymakcalan O; From the Laboratory of Bioregenerative Medicine & Surgery, Weill Cornell Medical College.; Department of Surgery, Division of Plastic Surgery., Veiseh O; Department of Bioengineering, Rice University.; Sigilon Therapeutics., Spector JA; From the Laboratory of Bioregenerative Medicine & Surgery, Weill Cornell Medical College.; Department of Surgery, Division of Plastic Surgery.; Meinig School of Biomedical Engineering, Cornell University.
Jazyk:	angličtina
Zdroj:	Plastic and reconstructive surgery [Plast Reconstr Surg] 2023 Oct 01; Vol. 152 (4), pp. 775-785. Date of Electronic Publication: 2023 Feb 28.
DOI:	10.1097/PRS.0000000000010323
Abstrakt:	Background: The body responds to prosthetic materials with an inflammatory foreign body response and deposition of a fibrous capsule, which may be deleterious to the function of the device and cause significant discomfort for the patient. Capsular contracture (CC) is the most common complication of aesthetic and reconstructive breast surgery. The source of significant patient morbidity, it can result in pain, suboptimal aesthetic outcomes, implant failure, and increased costs. The underlying mechanism remains unknown. Treatment is limited to reoperation and capsule excision, but recurrence rates remain high. In this study, the authors altered the surface chemistry of silicone implants with a proprietary anti-inflammatory coating to reduce capsule formation. Methods: Silicone implants were coated with Met-Z2-Y12, a biocompatible, anti-inflammatory surface modification. Uncoated and Met-Z2-Y12-coated implants were implanted in C57BL/6 mice. After 21, 90, or 180 days, periprosthetic tissue was removed for histologic analysis. Results: The authors compared mean capsule thickness at three time points. At 21, 90, and 180 days, there was a statistically significant reduction in capsule thickness of Met-Z2-Y12-coated implants compared with uncoated implants ( P < 0.05). Conclusions: Coating the surface of silicone implants with Met-Z2-Y12 significantly reduced acute and chronic capsule formation in a mouse model for implant-based breast augmentation and reconstruction. As capsule formation obligatorily precedes CC, these results suggest contracture itself may be significantly attenuated. Furthermore, as periprosthetic capsule formation is a complication without anatomical boundaries, this chemistry may have additional applications beyond breast implants, to a myriad of other implantable medical devices. Clinical Relevance Statement: Coating of the silicone implant surface with Met-Z2-Y12 alters the periprosthetic capsule architecture and significantly reduces capsule thickness for at least 6 months postoperatively in a murine model. This is a promising step forward in the development of a therapy to prevent capsular contracture. (Copyright © 2023 by the American Society of Plastic Surgeons.)
Databáze:	MEDLINE
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