Recent Trends in MALDI-MS Drugs Analysis in Human Hair: Pre-Analytical and Analytical Challenges and Pitfalls.

Autor:	Kernalléguen A; Inovie Labosud Provence, 8 rue Jean Queillau, Chemin de la Station, Marseille 13014, France.; Aix Marseille Univ, UMR-MD1 MT2, Inserm U-1261, MCT - Campus Timone, Faculté de Pharmacie, 27 Bd Jean Moulin, Marseille 13005, France.; Aix Marseille Univ, CNRS, EFS, ADES UMR 7268, Faculté des Sciences Médicales et paramédicales, 27 Bd Jean Moulin, Marseille 13385 cedex 5, France., Kintz P; Institut de Médecine Légale, 11, rue Humann, Strasbourg 67085, France., Leonetti G; Aix Marseille Univ, CNRS, EFS, ADES UMR 7268, Faculté des Sciences Médicales et paramédicales, 27 Bd Jean Moulin, Marseille 13385 cedex 5, France.; Service de Médecine Légale, Aix-Marseille Univ, 264, rue Saint Pierre, Marseille 13385 cedex 5, France., Lafitte D; Aix Marseille Univ, UMR-MD1 MT2, Inserm U-1261, MCT - Campus Timone, Faculté de Pharmacie, 27 Bd Jean Moulin, Marseille 13005, France., Pélissier-Alicot AL; Service de Médecine Légale, Aix-Marseille Univ, 264, rue Saint Pierre, Marseille 13385 cedex 5, France.
Jazyk:	angličtina
Zdroj:	Journal of analytical toxicology [J Anal Toxicol] 2023 May 19; Vol. 47 (5), pp. 417-428.
DOI:	10.1093/jat/bkad015
Abstrakt:	The value of hair in forensic toxicology has already been widely demonstrated. It offers a much wider detection window than other matrices, and its segmental analysis allows the documentation of a single, occasional or regular consumption of a large number of molecules. To date, considerable efforts are being made to achieve very high sensitivity using increasingly effective techniques in the forensic analysis of hair (gas chromatography with electron ionization mass spectrometry (GC--EI-MS); gas chromatography with chemical ionization mass spectrometry (GC--CI-MS); gas chromatography-tandem mass spectrometry (GC--MS-MS); high or ultra performance liquid chromatography-tandem mass spectrometry (HPLC-MS-MS and UPLC-MS-MS)). Since the early 2000s, work has been carried out to analyze hair using matrix-assisted laser desorption ionization (MALDI) coupled with imaging mass spectrometry (IMS). Intact, cut or pulverized, human head hairs are analyzed in all their forms. With a simplified and rapid sample preparation protocol, MALDI-IMS appears to be an attractive option for the forensic interpretation of hair analysis. The high spatial resolution clearly competes with conventional methods and strand segmentation. This article provides a complete overview on MALDI techniques used and its applications to better understand the pre-analytical and the analytical parts in the hair analysis. (© The Author(s) 2023. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
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