Inhibition of tumor necrosis factor receptor 1 and the risk of periodontitis.

Autor:	Alayash Z; Institute of Health Services Research in Dentistry, University of Münster, Münster, Germany., Baumeister SE; Institute of Health Services Research in Dentistry, University of Münster, Münster, Germany., Holtfreter B; Department of Restorative Dentistry, Periodontology, Endodontology, and Preventive and Pediatric Dentistry, University Medicine Greifswald, Greifswald, Germany., Kocher T; Department of Restorative Dentistry, Periodontology, Endodontology, and Preventive and Pediatric Dentistry, University Medicine Greifswald, Greifswald, Germany., Baurecht H; Department of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany., Ehmke B; Clinic for Periodontology and Conservative Dentistry, University of Münster, Münster, Germany., Reckelkamm SL; Institute of Health Services Research in Dentistry, University of Münster, Münster, Germany., Nolde M; Institute of Health Services Research in Dentistry, University of Münster, Münster, Germany.
Jazyk:	angličtina
Zdroj:	Frontiers in immunology [Front Immunol] 2023 Feb 09; Vol. 14, pp. 1094175. Date of Electronic Publication: 2023 Feb 09 (Print Publication: 2023).
DOI:	10.3389/fimmu.2023.1094175
Abstrakt:	Aim: To investigate the effect of genetically proxied inhibition of tumor necrosis factor receptor 1 (TNFR1) on the risk of periodontitis. Materials and Methods: Genetic instruments were selected from the vicinity of TNFR superfamily member 1A (TNFRSF1A) gene (chromosome 12; base pairs 6,437,923-6,451,280 as per GRCh37 assembly) based on their association with C-reactive protein (N= 575,531). Summary statistics of these variants were obtained from a genome-wide association study (GWAS) of 17,353 periodontitis cases and 28,210 controls to estimate the effect of TNFR1 inhibition on periodontitis using a fixed-effects inverse method. Results: Considering rs1800693 as an instrument, we found no effect of TNFR1 inhibition on periodontitis risk (Odds ratio (OR) scaled per standard deviation increment in CRP: 1.57, 95% confidence interval (CI): 0.38;6.46). Similar results were derived from a secondary analysis that used three variants (rs767455, rs4149570, and rs4149577) to index TNFR1 inhibition. Conclusions: We found no evidence of a potential efficacy of TNFR1 inhibition on periodontitis risk. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2023 Alayash, Baumeister, Holtfreter, Kocher, Baurecht, Ehmke, Reckelkamm and Nolde.)
Databáze:	MEDLINE
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