Xylans extracted from branches and leaves of Protium puncticulatum : antioxidant, cytotoxic, immunomodulatory, anticoagulant, antitumor, prebiotic activities and their structural characterization.

Autor: da Cruz Filho IJ; Department of Antibiotics, Biosciences Center, Federal University of Pernambuco, 50.670-420, Recife,, Pernambuco Brazil., de Souza TP; Department of Antibiotics, Biosciences Center, Federal University of Pernambuco, 50.670-420, Recife,, Pernambuco Brazil., Dos Anjos Santos CÁ; Department of Antibiotics, Biosciences Center, Federal University of Pernambuco, 50.670-420, Recife,, Pernambuco Brazil., de Morais Araújo MA; Department of Antibiotics, Biosciences Center, Federal University of Pernambuco, 50.670-420, Recife,, Pernambuco Brazil., de Oliveira Moraes Miranda JF; Department of Antibiotics, Biosciences Center, Federal University of Pernambuco, 50.670-420, Recife,, Pernambuco Brazil., de Oliveira Queirós ME; Department of Antibiotics, Biosciences Center, Federal University of Pernambuco, 50.670-420, Recife,, Pernambuco Brazil., Filho DJNC; Department of Antibiotics, Biosciences Center, Federal University of Pernambuco, 50.670-420, Recife,, Pernambuco Brazil., da Conceição Alves de Lima A; Department of Antibiotics, Biosciences Center, Federal University of Pernambuco, 50.670-420, Recife,, Pernambuco Brazil., Marques DSC; Department of Antibiotics, Biosciences Center, Federal University of Pernambuco, 50.670-420, Recife,, Pernambuco Brazil., do Carmo Alves de Lima M; Department of Antibiotics, Biosciences Center, Federal University of Pernambuco, 50.670-420, Recife,, Pernambuco Brazil.
Jazyk: angličtina
Zdroj: 3 Biotech [3 Biotech] 2023 Mar; Vol. 13 (3), pp. 93. Date of Electronic Publication: 2023 Feb 21.
DOI: 10.1007/s13205-023-03506-1
Abstrakt: This work aimed to isolate and characterize xylans from branches and leaves of Protium puncticulatum , in addition to evaluating its in vitro biological and prebiotic potential. The results showed that the chemical structure of the obtained polysaccharides is similar being classified as homoxylans. The xylans presented an amorphous structure, in addition to being thermally stable and presenting a molecular weight close to 36 g/mol. With regard to biological activities, it was observed that xylans were able to promote low antioxidant activity (< 50%) in the different assays evaluated. The xylans also showed no toxicity against normal cells, in addition to being able to stimulate cells of the immune system and showing promise as anticoagulant agents. In addition to presenting promising antitumor activity in vitro . In assays of emulsifying activity, xylans were able to emulsify lipids in percentages below 50%. Regarding in vitro prebiotic activity, xylans were able to stimulate and promote the growth of different probiotics. Therefore, this study, in addition to being a pioneer, contributes to the application of these polysaccharides in the biomedical and food areas.
Supplementary Information: The online version contains supplementary material available at 10.1007/s13205-023-03506-1.
Competing Interests: Conflict of interestThe authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(© King Abdulaziz City for Science and Technology 2023, Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.)
Databáze: MEDLINE
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