Host-Guest Encapsulation of RIBO with TSC4X: Synthesis, Characterization, and Its Application by Physicochemical and Computational Investigations.
| Autor: | Ghosh B; Department of Chemistry, University of North Bengal, Darjeeling 734013, West Bengal, India., Roy N; Department of Chemistry, University of North Bengal, Darjeeling 734013, West Bengal, India., Mandal S; Department of Chemistry, National Institute of Technology, Durgapur 713209, India., Ali S; Department of Chemistry, University of North Bengal, Darjeeling 734013, West Bengal, India., Bomzan P; Department of Chemistry, Gorubathan Government College, Kalimpong 735231, India., Roy D; Department of Chemistry, University of North Bengal, Darjeeling 734013, West Bengal, India., Salman Haydar M; Department of Botany, University of North Bengal, Darjeeling 734013, India., Dakua VK; Department of Chemistry, Alipurduar University, Alipurduar 736122, West Bengal, India., Upadhyay A; Department of Chemistry, Alipurduar University, Alipurduar 736122, West Bengal, India., Biswas D; Department of Chemistry, Alipurduar University, Alipurduar 736122, West Bengal, India., Paul KK; Department of Chemistry, Alipurduar University, Alipurduar 736122, West Bengal, India., Roy MN; Department of Chemistry, University of North Bengal, Darjeeling 734013, West Bengal, India. |
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| Jazyk: | angličtina |
| Zdroj: | ACS omega [ACS Omega] 2023 Feb 07; Vol. 8 (7), pp. 6778-6790. Date of Electronic Publication: 2023 Feb 07 (Print Publication: 2023). |
| DOI: | 10.1021/acsomega.2c07396 |
| Abstrakt: | In our present work, we synthesized a new encapsulated complex denoted as RIBO-TSC4X, which was derived from an important vitamin riboflavin (RIBO) and p -sulfonatothiacalix[4]arene(TSC4X). The synthesized complex RIBO-TSC4X was then characterized by utilizing several spectroscopic techniques such as 1 H-NMR, FT-IR, PXRD, SEM, and TGA. Job's plot has been employed to show the encapsulation of RIBO (guest) with TSC4X (host) having a 1:1 molar ratio. The molecular association constant of the complex entity (RIBO-TSC4X) was found to be 3116.29 ± 0.17 M -1 , suggesting the formation of a stable complex. The augment in aqueous solubility of the RIBO-TSC4X complex compared to pure RIBO was investigated by UV-vis spectroscopy, and it was viewed that the newly synthesized complex has almost 30 times enhanced solubility over pure RIBO. The enhancement of thermal stability upto 440 °C for the RIBO-TSC4X complex was examined by TG analysis. This research also forecasts RIBO's release behavior in the presence of CT-DNA, and at the same time, BSA binding study was also carried out. The synthesized RIBO-TSC4X complex exhibited comparatively better free radical scavenging activity, thereby minimizing oxidative injury of the cell as evident from a series of antioxidant and anti-lipid peroxidation assay. Furthermore, the RIBO-TSC4X complex showed peroxidase-like biomimetic activity, which is very useful for several enzyme catalyst reactions. Competing Interests: The authors declare no competing financial interest. (© 2023 The Authors. Published by American Chemical Society.) |
| Databáze: | MEDLINE |
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