The Landscape of Neutralizing Monoclonal Antibodies (nAbs) for Treatment and Prevention of COVID-19.

Autor: de Almeida Oliveira A; Immunobiological Technology Institute, Bio-Manguinhos/Fiocruz, Oswaldo Cruz Foundation, Avenida Brasil, 4.365, NAPA, Manguinhos, Rio de Janeiro, RJ 21040‑900 Brazil., Praia Borges Freire D; Immunobiological Technology Institute, Bio-Manguinhos/Fiocruz, Oswaldo Cruz Foundation, Avenida Brasil, 4.365, NAPA, Manguinhos, Rio de Janeiro, RJ 21040‑900 Brazil., Rodrigues de Andrade A; Immunobiological Technology Institute, Bio-Manguinhos/Fiocruz, Oswaldo Cruz Foundation, Avenida Brasil, 4.365, NAPA, Manguinhos, Rio de Janeiro, RJ 21040‑900 Brazil., de Miranda Marques A; Immunobiological Technology Institute, Bio-Manguinhos/Fiocruz, Oswaldo Cruz Foundation, Avenida Brasil, 4.365, NAPA, Manguinhos, Rio de Janeiro, RJ 21040‑900 Brazil., da Silva Madeira L; Immunobiological Technology Institute, Bio-Manguinhos/Fiocruz, Oswaldo Cruz Foundation, Avenida Brasil, 4.365, NAPA, Manguinhos, Rio de Janeiro, RJ 21040‑900 Brazil., Moreno Senna JP; Immunobiological Technology Institute, Bio-Manguinhos/Fiocruz, Oswaldo Cruz Foundation, Avenida Brasil, 4.365, NAPA, Manguinhos, Rio de Janeiro, RJ 21040‑900 Brazil., Freitas Brasileiro da Silveira IA; Immunobiological Technology Institute, Bio-Manguinhos/Fiocruz, Oswaldo Cruz Foundation, Avenida Brasil, 4.365, NAPA, Manguinhos, Rio de Janeiro, RJ 21040‑900 Brazil., de Castro Fialho B; Immunobiological Technology Institute, Bio-Manguinhos/Fiocruz, Oswaldo Cruz Foundation, Avenida Brasil, 4.365, NAPA, Manguinhos, Rio de Janeiro, RJ 21040‑900 Brazil.
Jazyk: angličtina
Zdroj: Journal of pharmaceutical innovation [J Pharm Innov] 2023 Feb 20, pp. 1-19. Date of Electronic Publication: 2023 Feb 20.
DOI: 10.1007/s12247-023-09713-w
Abstrakt: Purpose: After nearly 3 years of the COVID-19 pandemic, even though a vast body of knowledge and products (including vaccines and treatments) have been developed and disseminated, the virus is still evolving and new variants arising. Consequently, thousands of lives continue to be lost. Neutralizing monoclonal antibodies (nAbs) are promising drugs that emerged to treat SARS-CoV-2. In the uncertainty of the current situation, there is the question of whether organizations should continue to invest in this technology. To help decision-making in scientifical and pharmaceutical organizations, it is of major importance to monitor the development of products and technologies. Therefore, the aim of this study is analyze the landscape of nAbs for COVID-19.
Methods: The scenario of 473 biotherapeutics focusing on nAbs was evaluated using foresight techniques and a review of literature. Data were obtained from structured and semi-structured databases and processed for treatment, cleaning, consistency, validation, and enrichment.
Results: We identified 227 nAbs and performed an extensive literature review of 16 nAbs in late clinical development, including development technologies, responses to variants of concern (VOCs), manufacturing, and clinical aspects.
Conclusions: Even though the emergence of new VOCs is a threat to the effectiveness of this treatment, demanding constant genomic surveillance, the use of nAbs to treat and prevent COVID-19 will probably continue to be relevant due to excellent safety profiles and the possibility of immediate immunity transfer, especially in patients showing inadequate immunological response to vaccination. Therefore, we suggest that organizations should keep investing in improvements in this technology.
Competing Interests: Competing InterestsThe authors declare no competing interests.
(© The Author(s) 2023, Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.)
Databáze: MEDLINE
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