Real-world efficacy and safety of vedolizumab in managing ulcerative colitis versus Crohn's disease: results from an Italian multicenter study.

Autor:	Mocci G; Division of Gastroenterology, 'Brotzu' Hospital, Cagliari, Italy., Tursi A; Territorial Gastroenterology Service, ASL BAT, Andria, Italy.; Department of Medical and Surgical Sciences, Catholic University, School of Medicine, Rome, Italy., Maconi G; Division of Gastroenterology, 'L. Sacco' University Hospital, Milan, Italy., Cataletti G; Division of Gastroenterology, 'L. Sacco' University Hospital, Milan, Italy., Mantia B; Division of Gastroenterology, 'L. Sacco' University Hospital, Milan, Italy., Serio M; Division of Gastroenterology, 'San Salvatore' Hospital, Pesaro, Italy., Scarcelli A; Division of Gastroenterology, 'San Salvatore' Hospital, Pesaro, Italy., Pagnini C; Division of Gastroenterology, 'S. Giovanni - Addolorata' Hospital, Rome, Italy., Graziani MG; Division of Gastroenterology, 'S. Giovanni - Addolorata' Hospital, Rome, Italy., Di Paolo MC; Division of Gastroenterology, 'S. Giovanni - Addolorata' Hospital, Rome, Italy., Pranzo G; Ambulatory for IBD Treatment, 'Valle D'Itria' Hospital, Martina Franca (TA), Italy., Luppino I; Division of Gastroenterology, 'Annunziata' Hospital, Cosenza, Italy., Paese P; Division of Gastroenterology, 'Annunziata' Hospital, Cosenza, Italy., Elisei W; Division of Gastroenterology, A.O. 'S. Camillo-Folanini', Rome, Italy., Monterubbianesi R; Division of Gastroenterology, A.O. 'S. Camillo-Folanini', Rome, Italy., Faggiani R; Division of Gastroenterology, A.O. 'S. Camillo-Folanini', Rome, Italy., Ferronato A; Digestive Endoscopy Unit, ULSS7 Pedemontana, Santorso (VI), Italy., Perini B; Gastroenterology Unit, Azienda Ospedale-Università di Padova (AOUP), Padua, Italy., Savarino E; Gastroenterology Unit, Azienda Ospedale-Università di Padova (AOUP), Padua, Italy., Onidi FM; Division of Gastroenterology, 'Brotzu' Hospital, Cagliari, Italy., Binaghi L; Division of Gastroenterology, 'Brotzu' Hospital, Cagliari, Italy., Usai Satta P; Division of Gastroenterology, 'Brotzu' Hospital, Cagliari, Italy., Schiavoni E; Division of Internal Medicine and Gastroenterology, Department of Medical and Surgical Sciences, Policlinico Universitario 'A. Gemelli' IRCCS Foundation, Rome, Italy., Napolitano D; Division of Internal Medicine and Gastroenterology, Department of Medical and Surgical Sciences, Policlinico Universitario 'A. Gemelli' IRCCS Foundation, Rome, Italy., Scaldaferri F; Division of Internal Medicine and Gastroenterology, Department of Medical and Surgical Sciences, Policlinico Universitario 'A. Gemelli' IRCCS Foundation, Rome, Italy.; School of Medicine, Catholic University, Rome, Italy., Pugliese D; Division of Internal Medicine and Gastroenterology, Department of Medical and Surgical Sciences, Policlinico Universitario 'A. Gemelli' IRCCS Foundation, Rome, Italy.; School of Medicine, Catholic University, Rome, Italy., Pica R; Division of Gastroenterology, IBD Unit, 'S. Pertini' Hospital, Rome, Italy., Cocco A; Division of Gastroenterology, IBD Unit, 'S. Pertini' Hospital, Rome, Italy., Zippi M; Division of Gastroenterology, IBD Unit, 'S. Pertini' Hospital, Rome, Italy., Rodino S; Division of Gastroenterology, 'Ciaccio-Pugliese' Hospital, Catanzaro, Italy., Sebkova L; Division of Gastroenterology, 'Ciaccio-Pugliese' Hospital, Catanzaro, Italy., Rocco G; Division of Gastroenterology, 'Belcolle' Hospital, Viterbo, Italy., Sacchi C; Division of Gastroenterology, 'Belcolle' Hospital, Viterbo, Italy., Zampaletta C; Division of Gastroenterology, 'Belcolle' Hospital, Viterbo, Italy., Gaiani F; Gastroenterology and Endoscopy Unit, Department of Medicine and Surgery, University of Parma, Parma, Italy., De Angelis G; Gastroenterology and Endoscopy Unit, Department of Medicine and Surgery, University of Parma, Parma, Italy., Kayali S; Gastroenterology and Endoscopy Unit, Department of Medicine and Surgery, University of Parma, Parma, Italy., Fanigliulo L; Division of Gastroenterology, 'S.S. Annunziata' Hospital, Taranto, Italy., Lorenzetti R; Division of Gastroenterology, 'Nuovo Regina Margherita' Territorial Hospital, Roma, Italy., Allegretta L; Division of Gastroenterology, 'Santa Caterina Novella' Hospital, Galatina (LE), Italy., Scorza S; Division of Gastroenterology, 'Santa Caterina Novella' Hospital, Galatina (LE), Italy., Cuomo A; Division of Gastroenterology, 'Umberto I' Hospital, Nocera Inferiore (SA), Italy., Donnarumma L; Division of Gastroenterology, 'Umberto I' Hospital, Nocera Inferiore (SA), Italy., Della Valle N; Division of Gastroenterology, A.O. 'Ospedali Riuniti', Foggia, Italy., Sacco R; Division of Gastroenterology, A.O. 'Ospedali Riuniti', Foggia, Italy., Forti G; Division of Digestive Endoscopy, 'S. Maria Goretti' Hospital, Latina, Italy., Antonelli E; Gastroenterology & Hepatology Section, Department of Medicine & Surgery, University of Perugia, Perugia, Italy., Bassotti G; Gastroenterology & Hepatology Section, Department of Medicine & Surgery, University of Perugia, Perugia, Italy., Iannelli C; Department of Health Science, University of Catanzaro, Catanzaro, Italy., Luzza F; Department of Health Science, University of Catanzaro, Catanzaro, Italy., Aragona G; Division of Gastroenterology, 'Guglielmo da Saliceto' Hospital, Piacenza, Italy., Perazzo P; Division of Gastroenterology, 'Guglielmo da Saliceto' Hospital, Piacenza, Italy., Lauria A; Division of Gastroenterology, A.O. 'Bianchi-Melacrino-Morelli', Reggio Calabria, Italy., Piergallini S; Division of Gastroenterology, IBD Unit, 'A. Murri' Hospital, Fermo, Italy., Colucci R; Digestive Endoscopy Unit, 'San Matteo degli Infermi' Hospital, Spoleto (PG), Italy., Bianco MA; Division of Gastroenterology, 'T. Maresca' Hospital, Torre del Greco (NA), Italy., Meucci C; Division of Gastroenterology, 'T. Maresca' Hospital, Torre del Greco (NA), Italy., Giorgetti G; Digestive Endoscopy and Nutritional Unit, 'S. Eugenio' Hospital, Rome, Italy., Clemente V; Digestive Endoscopy and Nutritional Unit, 'S. Eugenio' Hospital, Rome, Italy., Fiorella S; Division of Gastroenterology, 'Padre Pio' Hospital, Vasto (CH), Italy., Penna A; Territorial Gastroenterology Service, ASL BA, Bari, Italy., De Medici A; Territorial Gastroenterology Service, PST Catanzaro Lido, Catanzaro, Italy., Picchio M; Division of General Surgery, 'P. Colombo' Hospital, Velletri (Roma), Italy., Papa A; Division of Internal Medicine and Gastroenterology, Department of Medical and Surgical Sciences, Policlinico Universitario 'A. Gemelli' IRCCS Foundation, Rome, Italy.; School of Medicine, Catholic University, Rome, Italy.
Jazyk:	angličtina
Zdroj:	Expert opinion on biological therapy [Expert Opin Biol Ther] 2023 Mar; Vol. 23 (3), pp. 293-304. Date of Electronic Publication: 2023 Mar 02.
DOI:	10.1080/14712598.2023.2185510
Abstrakt:	Background: Vedolizumab (VDZ) can be used to treat refractory ulcerative colitis (UC) and Crohn's disease (CD). We assessed whether there are differences in treating UC vs CD with VDZ. Research Design and Methods: Mayo score in UC and the Harvey-Bradshaw Index (HBI) in CD scored the clinical activity. Achievement and maintenance of clinical remission during the follow-up, and safety were the primary endpoints. Results: 729 patients (475 with UC and 254 with CD), median follow-up of 18 (IQR 6-36) months, were enrolled. Clinical remission at the 6 th month of treatment was achieved in 488 (66.9%) patients (74.4% in CD vs 62.9% in UC, p<0.002) while, during the follow-up, no difference was found (81.5% in the UC group and 81.5% pts in the CD group; p=0.537). The clinical remission at the 6 th month of treatment (p=0.001) and being naïve to biologics (p<0.0001) were significantly associated with prolonged clinical remission. The clinical response was significantly higher in UC (90.1%) vs CD (84.3%) (p=0.023), and surgery occurred more frequently in CD (1.9% in UC vs 5.1% in CD, p=0.016). Conclusion: We found differences when using VDZ in UC vs CD in real life. These parameters can help the physician predict this drug's longterm efficacy.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu