Diagnostic challenges of renal medullary carcinoma and the role for cytologic assessment: Case report and literature review.

Autor: Severseike BO; Phoenix Children's Hospital Residency Program Alliance (PCHRP), Phoenix Children's Hospital, Phoenix, Arizona, USA., Schafernak KT; Pathology and Laboratory Medicine, Phoenix Children's Hospital, Phoenix, Arizona, USA.; Department of Child Health, University of Arizona College of Medicine, Phoenix, Arizona, USA.; Creighton University School of Medicine, Phoenix, Arizona, USA.; Mayo Clinic Alix School of Medicine, Phoenix, Arizona, USA., Willard SD; Department of Child Health, University of Arizona College of Medicine, Phoenix, Arizona, USA.; Creighton University School of Medicine, Phoenix, Arizona, USA.; Mayo Clinic Alix School of Medicine, Phoenix, Arizona, USA.; Interventional Radiology, Phoenix Children's Hospital, Phoenix, Arizona, USA., Goncalves LF; Department of Child Health, University of Arizona College of Medicine, Phoenix, Arizona, USA.; Creighton University School of Medicine, Phoenix, Arizona, USA.; Mayo Clinic Alix School of Medicine, Phoenix, Arizona, USA.; Radiology Department, Phoenix Children's Hospital, Phoenix, Arizona, USA., Kothari AK; Department of Child Health, University of Arizona College of Medicine, Phoenix, Arizona, USA.; Creighton University School of Medicine, Phoenix, Arizona, USA.; Mayo Clinic Alix School of Medicine, Phoenix, Arizona, USA.; Center for Cancer and Blood Disorders, Phoenix Children's Hospital, Phoenix, Arizona, USA., Eshun FK; Department of Child Health, University of Arizona College of Medicine, Phoenix, Arizona, USA.; Creighton University School of Medicine, Phoenix, Arizona, USA.; Mayo Clinic Alix School of Medicine, Phoenix, Arizona, USA.; Center for Cancer and Blood Disorders, Phoenix Children's Hospital, Phoenix, Arizona, USA., Mangum R; Department of Child Health, University of Arizona College of Medicine, Phoenix, Arizona, USA.; Creighton University School of Medicine, Phoenix, Arizona, USA.; Mayo Clinic Alix School of Medicine, Phoenix, Arizona, USA.; Center for Cancer and Blood Disorders, Phoenix Children's Hospital, Phoenix, Arizona, USA.
Jazyk: angličtina
Zdroj: Journal of clinical laboratory analysis [J Clin Lab Anal] 2023 Apr; Vol. 37 (4), pp. e24854. Date of Electronic Publication: 2023 Feb 26.
DOI: 10.1002/jcla.24854
Abstrakt: Background: Renal medullary carcinoma (RMC) is a diagnostically challenging, aggressive primary renal malignancy associated with abysmal survival. Delays in diagnosis contribute to most patients having diffusely metastatic disease at the time of initial presentation.
Methods: We present the case of a 13-year-old African American male with sickle cell trait who presented with a renal mass and hematuria. Evaluation included imaging, fluid cultures, and cytologic assessment.
Results: Patient was diagnosed with RMC based on cytologic assessment of sub-centimeter fluid collections aspirated from the left kidney at the time of cortical biopsy for suspected renal mass. The additional fluid aspiration in conjunction with renal biopsy was an atypical but crucial step in early diagnosis.
Conclusion: Cytomorphologic evaluation of fluid biospecimens is not currently part of the standard work-up for patients with renal masses but, when available, can provide crucial information that reduces time to diagnosis. Prompt symptom recognition and treatment initiation may improve patient outcomes.
(© 2023 The Authors. Journal of Clinical Laboratory Analysis published by Wiley Periodicals LLC.)
Databáze: MEDLINE
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