Intra-pituitary follicle-stimulating hormone signaling regulates hepatic lipid metabolism in mice.

Autor: Qiao S; Experimental Pharmacology, Center for Molecular Signaling (PZMS), Saarland University School of Medicine, Homburg, Germany.; Assisted Reproduction Center, Northwest Women's and Children's Hospital, Xi'an, China., Alasmi S; Experimental Pharmacology, Center for Molecular Signaling (PZMS), Saarland University School of Medicine, Homburg, Germany., Wyatt A; Experimental Pharmacology, Center for Molecular Signaling (PZMS), Saarland University School of Medicine, Homburg, Germany., Wartenberg P; Experimental Pharmacology, Center for Molecular Signaling (PZMS), Saarland University School of Medicine, Homburg, Germany., Wang H; Experimental Pharmacology, Center for Molecular Signaling (PZMS), Saarland University School of Medicine, Homburg, Germany., Candlish M; Experimental Pharmacology, Center for Molecular Signaling (PZMS), Saarland University School of Medicine, Homburg, Germany.; Institute of Cell Biology and Neuroscience, Buchmann Institute for Molecular Life Sciences, Goethe University Frankfurt, Frankfurt am Main, Germany., Das D; Experimental Pharmacology, Center for Molecular Signaling (PZMS), Saarland University School of Medicine, Homburg, Germany., Aoki M; Experimental Pharmacology, Center for Molecular Signaling (PZMS), Saarland University School of Medicine, Homburg, Germany., Grünewald R; Experimental Pharmacology, Center for Molecular Signaling (PZMS), Saarland University School of Medicine, Homburg, Germany., Zhou Z; Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada., Tian Q; Molecular Cell Biology, Center for Molecular Signaling (PZMS), Saarland University School of Medicine, Homburg, Germany., Yu Q; Experimental Pharmacology, Center for Molecular Signaling (PZMS), Saarland University School of Medicine, Homburg, Germany., Götz V; Experimental Pharmacology, Center for Molecular Signaling (PZMS), Saarland University School of Medicine, Homburg, Germany., Belkacemi A; Experimental Pharmacology, Center for Molecular Signaling (PZMS), Saarland University School of Medicine, Homburg, Germany., Raza A; Experimental Pharmacology, Center for Molecular Signaling (PZMS), Saarland University School of Medicine, Homburg, Germany., Ectors F; FARAH Mammalian Transgenics Platform, Liège University, Liège, Belgium., Kattler K; Department of Genetics and Epigenetics, Saarland University, Saarbrücken, Germany., Gasparoni G; Department of Genetics and Epigenetics, Saarland University, Saarbrücken, Germany., Walter J; Department of Genetics and Epigenetics, Saarland University, Saarbrücken, Germany., Lipp P; Molecular Cell Biology, Center for Molecular Signaling (PZMS), Saarland University School of Medicine, Homburg, Germany., Mollard P; IGF, University of Montpellier, CNRS, INSERM, Montpellier, France., Bernard DJ; Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada., Karatayli E; Department of Medicine II, Saarland University Medical Center, Saarland University, Homburg, Germany., Karatayli SC; Department of Medicine II, Saarland University Medical Center, Saarland University, Homburg, Germany., Lammert F; Department of Medicine II, Saarland University Medical Center, Saarland University, Homburg, Germany., Boehm U; Experimental Pharmacology, Center for Molecular Signaling (PZMS), Saarland University School of Medicine, Homburg, Germany. ulrich.boehm@uks.eu.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2023 Feb 25; Vol. 14 (1), pp. 1098. Date of Electronic Publication: 2023 Feb 25.
DOI: 10.1038/s41467-023-36681-z
Abstrakt: Inter-organ communication is a major hallmark of health and is often orchestrated by hormones released by the anterior pituitary gland. Pituitary gonadotropes secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH) to regulate gonadal function and control fertility. Whether FSH and LH also act on organs other than the gonads is debated. Here, we find that gonadotrope depletion in adult female mice triggers profound hypogonadism, obesity, glucose intolerance, fatty liver, and bone loss. The absence of sex steroids precipitates these phenotypes, with the notable exception of fatty liver, which results from ovary-independent actions of FSH. We uncover paracrine FSH action on pituitary corticotropes as a mechanism to restrain the production of corticosterone and prevent hepatic steatosis. Our data demonstrate that functional communication of two distinct hormone-secreting cell populations in the pituitary regulates hepatic lipid metabolism.
(© 2023. The Author(s).)
Databáze: MEDLINE
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