Therapeutic Potential of Dopamine and Related Drugs as Anti-Inflammatories and Antioxidants in Neuronal and Non-Neuronal Pathologies.

Autor: Bandala C; Neurociencia Básica, Instituto Nacional de Rehabilitación LGII, Secretaría de Salud, Mexico City 14389, Mexico.; Escuela Superior de Medicina, Instituto Politécnico Nacional, Mexico City 11340, Mexico., Cárdenas-Rodríguez N; Escuela Superior de Medicina, Instituto Politécnico Nacional, Mexico City 11340, Mexico.; Laboratorio de Neurociencias, Subdirección de Medicina Experimental, Instituto Nacional de Pediatría, Mexico City 04530, Mexico., Mendoza-Torreblanca JG; Laboratorio de Neurociencias, Subdirección de Medicina Experimental, Instituto Nacional de Pediatría, Mexico City 04530, Mexico., Contreras-García IJ; Laboratorio de Fisiología, Escuela Militar de Graduados de Sanidad, UDEFA, Mexico City 11200, Mexico., Martínez-López V; Unidad de Ingeniería de Tejidos, Terapia Celular y Medicina Regenerativa, Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra, Mexico City 14389, Mexico., Cruz-Hernández TR; Escuela Superior de Medicina, Instituto Politécnico Nacional, Mexico City 11340, Mexico., Carro-Rodríguez J; Escuela de Biología Experimental, Unidad Iztapalapa, Universidad Autónoma Metropolitana, Mexico City 09340, Mexico., Vargas-Hernández MA; Subdirección de Investigación, Escuela Militar de Graduados de Sanidad, Mexico City 11200, Mexico., Ignacio-Mejía I; Laboratorio de Medicina Traslacional, Escuela Militar de Graduados de Sanidad, Mexico City 11200, Mexico., Alfaro-Rodriguez A; Neurociencia Básica, Instituto Nacional de Rehabilitación LGII, Secretaría de Salud, Mexico City 14389, Mexico., Lara-Padilla E; Escuela Superior de Medicina, Instituto Politécnico Nacional, Mexico City 11340, Mexico.
Jazyk: angličtina
Zdroj: Pharmaceutics [Pharmaceutics] 2023 Feb 18; Vol. 15 (2). Date of Electronic Publication: 2023 Feb 18.
DOI: 10.3390/pharmaceutics15020693
Abstrakt: Dopamine (DA), its derivatives, and dopaminergic drugs are compounds widely used in the management of diseases related to the nervous system. However, DA receptors have been identified in nonneuronal tissues, which has been related to their therapeutic potential in pathologies such as sepsis or septic shock, blood pressure, renal failure, diabetes, and obesity, among others. In addition, DA and dopaminergic drugs have shown anti-inflammatory and antioxidant properties in different kinds of cells.
Aim: To compile the mechanism of action of DA and the main dopaminergic drugs and show the findings that support the therapeutic potential of these molecules for the treatment of neurological and non-neurological diseases considering their antioxidant and anti-inflammatory actions.
Method: We performed a review article. An exhaustive search for information was carried out in specialized databases such as PubMed, PubChem, ProQuest, EBSCO, Scopus, Science Direct, Web of Science, Bookshelf, DrugBank, Livertox, and Clinical Trials.
Results: We showed that DA and dopaminergic drugs have emerged for the management of neuronal and nonneuronal diseases with important therapeutic potential as anti-inflammatories and antioxidants.
Conclusions: DA and DA derivatives can be an attractive treatment strategy and a promising approach to slowing the progression of disorders through repositioning.
Databáze: MEDLINE
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