Increasing Bioavailability of Trans-Ferulic Acid by Encapsulation in Functionalized Mesoporous Silica.

Autor: Petrișor G; Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Chemical Engineering and Biotechnologies, University POLITEHNICA of Bucharest, Gh. Polizu 1-7, 011061 Bucharest, Romania.; National Research Center for Food Safety, University POLITEHNICA of Bucharest, Splaiul Independentei 313, 060042 Bucharest, Romania.; National Center for Micro and Nanomaterials, University POLITEHNICA of Bucharest, Splaiul Independentei 313, 060042 Bucharest, Romania., Motelica L; Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Chemical Engineering and Biotechnologies, University POLITEHNICA of Bucharest, Gh. Polizu 1-7, 011061 Bucharest, Romania.; National Research Center for Food Safety, University POLITEHNICA of Bucharest, Splaiul Independentei 313, 060042 Bucharest, Romania.; National Center for Micro and Nanomaterials, University POLITEHNICA of Bucharest, Splaiul Independentei 313, 060042 Bucharest, Romania., Ficai D; National Research Center for Food Safety, University POLITEHNICA of Bucharest, Splaiul Independentei 313, 060042 Bucharest, Romania.; National Center for Micro and Nanomaterials, University POLITEHNICA of Bucharest, Splaiul Independentei 313, 060042 Bucharest, Romania.; Department of Inorganic Chemistry, Physical Chemistry and Electrochemistry, Faculty of Chemical Engineering and Biotechnologies, University POLITEHNICA of Bucharest, Gh. Polizu 1-7, 011061 Bucharest, Romania., Ilie CI; Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Chemical Engineering and Biotechnologies, University POLITEHNICA of Bucharest, Gh. Polizu 1-7, 011061 Bucharest, Romania.; National Research Center for Food Safety, University POLITEHNICA of Bucharest, Splaiul Independentei 313, 060042 Bucharest, Romania.; National Center for Micro and Nanomaterials, University POLITEHNICA of Bucharest, Splaiul Independentei 313, 060042 Bucharest, Romania., Trușcǎ RD; Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Chemical Engineering and Biotechnologies, University POLITEHNICA of Bucharest, Gh. Polizu 1-7, 011061 Bucharest, Romania.; National Research Center for Food Safety, University POLITEHNICA of Bucharest, Splaiul Independentei 313, 060042 Bucharest, Romania.; National Center for Micro and Nanomaterials, University POLITEHNICA of Bucharest, Splaiul Independentei 313, 060042 Bucharest, Romania., Surdu VA; Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Chemical Engineering and Biotechnologies, University POLITEHNICA of Bucharest, Gh. Polizu 1-7, 011061 Bucharest, Romania.; National Research Center for Food Safety, University POLITEHNICA of Bucharest, Splaiul Independentei 313, 060042 Bucharest, Romania.; National Center for Micro and Nanomaterials, University POLITEHNICA of Bucharest, Splaiul Independentei 313, 060042 Bucharest, Romania., Oprea OC; National Research Center for Food Safety, University POLITEHNICA of Bucharest, Splaiul Independentei 313, 060042 Bucharest, Romania.; National Center for Micro and Nanomaterials, University POLITEHNICA of Bucharest, Splaiul Independentei 313, 060042 Bucharest, Romania.; Department of Inorganic Chemistry, Physical Chemistry and Electrochemistry, Faculty of Chemical Engineering and Biotechnologies, University POLITEHNICA of Bucharest, Gh. Polizu 1-7, 011061 Bucharest, Romania.; Academy of Romanian Scientists, Ilfov Street 3, 050044 Bucharest, Romania., Mȋrț AL; Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Chemical Engineering and Biotechnologies, University POLITEHNICA of Bucharest, Gh. Polizu 1-7, 011061 Bucharest, Romania.; National Research Center for Food Safety, University POLITEHNICA of Bucharest, Splaiul Independentei 313, 060042 Bucharest, Romania.; National Center for Micro and Nanomaterials, University POLITEHNICA of Bucharest, Splaiul Independentei 313, 060042 Bucharest, Romania.; National Institute for Research & Development in Chemistry and Petrochemistry-ICECHIM, 202 Spl. Independentei, 060021 Bucharest, Romania., Vasilievici G; National Institute for Research & Development in Chemistry and Petrochemistry-ICECHIM, 202 Spl. Independentei, 060021 Bucharest, Romania., Semenescu A; Department Engineering and Management for Transports, University POLITEHNICA of Bucharest, 060042 Bucharest, Romania., Ficai A; Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Chemical Engineering and Biotechnologies, University POLITEHNICA of Bucharest, Gh. Polizu 1-7, 011061 Bucharest, Romania.; National Research Center for Food Safety, University POLITEHNICA of Bucharest, Splaiul Independentei 313, 060042 Bucharest, Romania.; National Center for Micro and Nanomaterials, University POLITEHNICA of Bucharest, Splaiul Independentei 313, 060042 Bucharest, Romania.; Academy of Romanian Scientists, Ilfov Street 3, 050044 Bucharest, Romania., Dițu LM; Department of Microbiology and Immunology, Faculty of Biology, University of Bucharest, 1-3 Aleea Portocalelor, 060101 Bucharest, Romania.; Research Institute of the University of Bucharest, 050095 Bucharest, Romania.
Jazyk: angličtina
Zdroj: Pharmaceutics [Pharmaceutics] 2023 Feb 16; Vol. 15 (2). Date of Electronic Publication: 2023 Feb 16.
DOI: 10.3390/pharmaceutics15020660
Abstrakt: Two types of mesoporous materials, MCM-41 and MCM-48, were functionalized by the soft-template method using (3-aminopropyl)triethoxysilane (APTES) as a modifying agent. The obtained mesoporous silica materials were loaded with trans-ferulic acid (FA). In order to establish the morphology and structure of mesoporous materials, a series of specific techniques were used such as: X-ray Diffraction (XRD), Scanning Electron Microscopy (SEM), Brunauer-Emmet-Teller (BET), Fourier Transform Infrared Spectroscopy (FTIR) and thermogravimetric analysis (TGA). We monitored the in vitro release of the loaded FA at two different pH values, by using simulated gastric fluid (SGF) and simulated intestinal fluid (SIF). Additionally, Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853 and Candida albicans ATCC 10231 were used to evaluate the antimicrobial activity of FA loaded mesoporous silica materials. In conclusion such functionalized mesoporous materials can be employed as controlled release systems for polyphenols extracted from natural sources.
Databáze: MEDLINE
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