Dietary Inflammatory Index, Obesity, and the Incidence of Colorectal Cancer: Findings from a Hospital-Based Case-Control Study in Malaysia.

Autor: Shafiee NH; Department of Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, Cheras, Kuala Lumpur 56000, Malaysia., Razalli NH; Dietetics Programme, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur 50300, Malaysia.; GUT Research Group, Department of Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, Cheras, Kuala Lumpur 56000, Malaysia.; Centre for Healthy Ageing and Wellness (HCARE), Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur 50300, Malaysia., Shahril MR; Centre for Healthy Ageing and Wellness (HCARE), Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur 50300, Malaysia., Muhammad Nawawi KN; GUT Research Group, Department of Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, Cheras, Kuala Lumpur 56000, Malaysia.; Gastroenterology Unit, Department of Medicine, Universiti Kebangsaan Malaysia, Cheras, Kuala Lumpur 56000, Malaysia., Mohd Mokhtar N; GUT Research Group, Department of Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, Cheras, Kuala Lumpur 56000, Malaysia.; Department of Physiology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Cheras, Kuala Lumpur 56000, Malaysia., Abd Rashid AA; Nutrition and Dietetics Programme, School of Health Sciences, Universiti Sains Malaysia, Kota Bharu 16150, Malaysia., Ashari LS; Nutrition and Dietetics Programme, School of Health Sciences, Universiti Sains Malaysia, Kota Bharu 16150, Malaysia., Jan Mohamed HJ; Nutrition and Dietetics Programme, School of Health Sciences, Universiti Sains Malaysia, Kota Bharu 16150, Malaysia., Raja Ali RA; GUT Research Group, Department of Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, Cheras, Kuala Lumpur 56000, Malaysia.; School of Medical and Life Sciences, Sunway University, Petaling Jaya 47500, Malaysia.
Jazyk: angličtina
Zdroj: Nutrients [Nutrients] 2023 Feb 16; Vol. 15 (4). Date of Electronic Publication: 2023 Feb 16.
DOI: 10.3390/nu15040982
Abstrakt: Obesity-mediated inflammation represents a key connection between the intake of foods with high inflammatory potential and colorectal cancer (CRC) risk. We aimed to explore the association between energy-adjusted dietary inflammatory index (E-DII) in relation to CRC risk in both obese and non-obese subjects. This study included 99 histopathologically confirmed CRC cases, 73 colonic polyps cases, and 141 healthy controls from tertiary medical centres in both urban and suburban areas in Peninsular Malaysia. The subjects were categorised into body mass index (BMI) < 25 kg/m 2 and BMI ≥ 25 kg/m 2 groups. E-DII scores were computed based on dietary intake assessed using a validated food frequency questionnaire (FFQ). Logistic regression models were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs), adjusted for potential cofounders. The mean dietary energy intake and mean BMI values of the subjects tended to increase as the E-DII scores increased ( p for trend < 0.001). E-DII was significantly related to CRC risk only in obese subjects (OR = 1.45; 95% CI = 1.30-1.77; p < 0.001 for trend). Stratified analyses of risk factors showed significant associations between E-DII and CRC risk by age group ( p for interaction = 0.030), smoking status ( p for interaction = 0.043), and anthropometric indices for both males and females ( p for interaction < 0.001) in the most pro-inflammatory E-DII quartile vs. the lowest E-DII quartile. Overall, pro-inflammatory diets were associated with an increased incidence of CRC in the Malaysian population, particularly in obese subjects.
Databáze: MEDLINE
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