Possible Combined Effects of Plasma Folate Levels, Global DNA Methylation, and Blood Cadmium Concentrations on Renal Cell Carcinoma.

Autor: Huang CY; Department of Urology, National Taiwan University Hospital, College of Medicine National Taiwan University, Taipei City 110, Taiwan., Chen WJ; Department of Medicine, Section of Epidemiology and Population Sciences, Baylor College of Medicine, Houston, TX 77030, USA., Lee HL; Department of Chemistry, Fu Jen Catholic University, New Taipei City 242, Taiwan., Lin YC; Department of Family Medicine, Wan Fang Hospital, Taipei Medical University, Taipei City 110, Taiwan.; Department of Family Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei City 110, Taiwan.; Department of Occupational Medicine, Wan Fang Hospital, Taipei Medical University, Taipei City 110, Taiwan., Huang YL; Department of Public Health, School of Medicine, College of Medicine, Taipei Medical University, Taipei City 110, Taiwan., Shiue HS; Department of Chinese Medicine, College of Medicine, Chang Gung University, Taoyuan City 333, Taiwan., Pu YS; Department of Urology, National Taiwan University Hospital, College of Medicine National Taiwan University, Taipei City 110, Taiwan., Hsueh YM; Department of Family Medicine, Wan Fang Hospital, Taipei Medical University, Taipei City 110, Taiwan.; Department of Public Health, School of Medicine, College of Medicine, Taipei Medical University, Taipei City 110, Taiwan.
Jazyk: angličtina
Zdroj: Nutrients [Nutrients] 2023 Feb 13; Vol. 15 (4). Date of Electronic Publication: 2023 Feb 13.
DOI: 10.3390/nu15040937
Abstrakt: Epigenetic effects of environmental pollutants may be related to carcinogenesis. This study aimed to explore the association between the global DNA methylation marker: 5-methyl-2-deoxycytidine (5mdC) and renal cell carcinoma (RCC), and further investigated whether plasma folate and vitamin B 12 levels and 5mdC modified the association between blood cadmium concentrations and RCC. We recruited 174 RCC patients and 673 non-RCC controls. Blood cadmium concentrations, plasma folate and vitamin B 12 levels were measured. The amount of 5mdC in the DNA sample was expressed as percentages of the total cytosine content. An increase of 5mdC (%) and plasma folate and vitamin B 12 levels were associated with decreasing odds ratio (OR) of RCC. Although plasma folate levels were not directly associated with 5mdC (%), a combined effect was observed with the odds of low plasma folate levels and low 5mdC (%) were greater among RCC patients compared to controls (OR (95% confidence interval, CI) = 11.86 (5.27-26.65)). Additionally, we observed that the odds of low plasma folate and high blood cadmium levels were greater among RCC patients than in controls (OR (95% CI): 8.15 (1.39-7.13)). This study provides suggestive evidence that plasma folate levels may modify the associations between 5mdC (%) or blood cadmium concentrations and RCC.
Databáze: MEDLINE
Externí odkaz: