Staphylococcus aureus Host Spectrum Correlates with Methicillin Resistance in a Multi-Species Ecosystem.

Autor:	Ngoubangoye B; Centre Interdisciplinaire de Recherches Médicales de Franceville (CIRMF), Franceville BP 769, Gabon.; CNRS, Laboratoire de Biométrie et Biologie Evolutive UMR5558, Université de Lyon 1, 69622 Villeurbanne, France.; LabEx ECOFECT, Eco-Evolutionary Dynamics of Infectious Diseases, Université de Lyon 1, 69622 Villeurbanne, France., Fouchet D; CNRS, Laboratoire de Biométrie et Biologie Evolutive UMR5558, Université de Lyon 1, 69622 Villeurbanne, France.; LabEx ECOFECT, Eco-Evolutionary Dynamics of Infectious Diseases, Université de Lyon 1, 69622 Villeurbanne, France., Boundenga LA; Centre Interdisciplinaire de Recherches Médicales de Franceville (CIRMF), Franceville BP 769, Gabon., Cassan C; Laboratoire MIVEGEC, UMR-CNRS 5290-IRD 224, IRD Montpellier, 34394 Montpellier, France., Arnathau C; Laboratoire MIVEGEC, UMR-CNRS 5290-IRD 224, IRD Montpellier, 34394 Montpellier, France., Meugnier H; Centre National de Référence des Staphylocoques, Institut des Agent infectieux, Hôpital de la Croix Rousse, Hospices Civils de Lyon, 69004 Lyon, France., Tsoumbou TA; Centre Interdisciplinaire de Recherches Médicales de Franceville (CIRMF), Franceville BP 769, Gabon., Dibakou SE; Centre Interdisciplinaire de Recherches Médicales de Franceville (CIRMF), Franceville BP 769, Gabon., Otsaghe Ekore D; Centre Interdisciplinaire de Recherches Médicales de Franceville (CIRMF), Franceville BP 769, Gabon., Nguema YO; Centre Interdisciplinaire de Recherches Médicales de Franceville (CIRMF), Franceville BP 769, Gabon., Moukodoum ND; Centre Interdisciplinaire de Recherches Médicales de Franceville (CIRMF), Franceville BP 769, Gabon., Mabicka A; Centre Interdisciplinaire de Recherches Médicales de Franceville (CIRMF), Franceville BP 769, Gabon., Ferry T; LabEx ECOFECT, Eco-Evolutionary Dynamics of Infectious Diseases, Université de Lyon 1, 69622 Villeurbanne, France.; Laboratoire de Bactériologie, Observatoire Rhône-Alpes des Mycobactéries, Institut des Agents Infectieux, Hospices Civil, 69004 Lyon, France., Rasigade JP; LabEx ECOFECT, Eco-Evolutionary Dynamics of Infectious Diseases, Université de Lyon 1, 69622 Villeurbanne, France.; Centre International de Recherche en Infectiologie, INSERM U1111, CNRS UMR5308, Université de Lyon 1, ENS de Lyon, Hospices Civil Lyon, 69004 Lyon, France., Prugnolle F; Centre Interdisciplinaire de Recherches Médicales de Franceville (CIRMF), Franceville BP 769, Gabon.; Laboratoire MIVEGEC, UMR-CNRS 5290-IRD 224, IRD Montpellier, 34394 Montpellier, France., Bañuls AL; Laboratoire MIVEGEC, UMR-CNRS 5290-IRD 224, IRD Montpellier, 34394 Montpellier, France., Renaud F; Laboratoire MIVEGEC, UMR-CNRS 5290-IRD 224, IRD Montpellier, 34394 Montpellier, France., Pontier D; CNRS, Laboratoire de Biométrie et Biologie Evolutive UMR5558, Université de Lyon 1, 69622 Villeurbanne, France.; LabEx ECOFECT, Eco-Evolutionary Dynamics of Infectious Diseases, Université de Lyon 1, 69622 Villeurbanne, France.
Jazyk:	angličtina
Zdroj:	Microorganisms [Microorganisms] 2023 Feb 03; Vol. 11 (2). Date of Electronic Publication: 2023 Feb 03.
DOI:	10.3390/microorganisms11020393
Abstrakt:	Although antibiotic resistance is a major issue for both human and animal health, very few studies have investigated the role of the bacterial host spectrum in its dissemination within natural ecosystems. Here, we assessed the prevalence of methicillin resistance among Staphylococcus aureus (MRSA) isolates from humans, non-human primates (NHPs), micromammals and bats in a primatology center located in southeast Gabon, and evaluated the plausibility of four main predictions regarding the acquisition of antibiotic resistance in this ecosystem. MRSA strain prevalence was much higher in exposed species (i.e., humans and NHPs which receive antibiotic treatment) than in unexposed species (micromammals and bats), and in NHP species living in enclosures than those in captivity-supporting the assumption that antibiotic pressure is a risk factor in the acquisition of MRSA that is reinforced by the irregularity of drug treatment. In the two unexposed groups of species, resistance prevalence was high in the generalist strains that infect humans or NHPs, supporting the hypothesis that MRSA strains diffuse to wild species through interspecific transmission of a generalist strain. Strikingly, the generalist strains that were not found in humans showed a higher proportion of MRSA strains than specialist strains, suggesting that generalist strains present a greater potential for the acquisition of antibiotic resistance than specialist strains. The host spectrum is thus a major component of the issue of antibiotic resistance in ecosystems where humans apply strong antibiotic pressure.
Databáze:	MEDLINE
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