| Autor: |
Caprara CDSC; Laboratório de Desenvolvimento de Novos Fármacos (LADEFA), Universidade Federal do Rio Grande (FURG), Rio Grande 96200-400, RS, Brazil., Mathias TK; NMR Laboratory, NMR Center, Departamento de Química, Universidade Federal do Paraná, Curitiba 81530-900, PR, Brazil., Santos MFC; NMR Laboratory, NMR Center, Departamento de Química, Universidade Federal do Paraná, Curitiba 81530-900, PR, Brazil., D'Oca MGM; NMR Laboratory, NMR Center, Departamento de Química, Universidade Federal do Paraná, Curitiba 81530-900, PR, Brazil., D'Oca CDRM; NMR Laboratory, NMR Center, Departamento de Química, Universidade Federal do Paraná, Curitiba 81530-900, PR, Brazil., Roselet F; Laboratório de Produção de Microalgas (LPM), Instituto de Oceanografia, Universidade Federal do Rio Grande (FURG), Rio Grande 96210-030, RS, Brazil., Abreu PC; Laboratório de Produção de Microalgas (LPM), Instituto de Oceanografia, Universidade Federal do Rio Grande (FURG), Rio Grande 96210-030, RS, Brazil., Ramos DF; Laboratório de Desenvolvimento de Novos Fármacos (LADEFA), Universidade Federal do Rio Grande (FURG), Rio Grande 96200-400, RS, Brazil.; Núcleo de Desenvolvimento de Novos Fármacos-NUDEFA, Rua General Osório, s/n°, Campus Saúde, 2° andar, Rio Grande 96200-400, RS, Brazil. |
| Abstrakt: |
Natural products from the marine environment as well as microalgae, have been known for the complexity of the metabolites they produce due to their adaptability to different environmental conditions, which has been an inexhaustible source of several bioactive properties, such as antioxidant, anti-tumor, and antimicrobial. This study aims to characterize the main metabolites of three species of microalgae ( Nannochloropsis oceanica , Chaetoceros muelleri, and Conticribra weissflogii ), which have important applications in the biofuel and nutrition industries, by 1 H High-resolution magic angle spinning nuclear magnetic resonance ( 1 H HR-MAS NMR), a method which is non-destructive, is highly reproducible, and requires minimal sample preparation. Even though the three species were found in the same ecosystem and a superior production of lipid compounds was observed, important differences were identified in relation to the production of specialized metabolites. These distinct properties favor the use of these compounds as leaders in the development of new bioactive compounds, especially against environmental, human, and animal pathogens (One Health), and demonstrate their potential in the development of alternatives for aquaculture. |
