Differences and Similarities in Empathy Deficit and Its Neural Basis between Logopenic and Amnesic Alzheimer's Disease.

Autor:	Giacomucci G; Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, 50134 Florence, Italy., Polito C; IRCCS Fondazione Don Carlo Gnocchi, 50143 Florence, Italy., Berti V; Department of Biomedical, Experimental and Clinical Sciences 'Mario Serio', University of Florence, 50134 Florence, Italy.; Nuclear Medicine Unit, Azienda Ospedaliero-Universitaria Careggi, 50134 Florence, Italy., Padiglioni S; Regional Referral Centre for Relational Criticalities-Tuscany Region, 50134 Florence, Italy.; Research and Innovation Centre for Dementia-CRIDEM, AOU Careggi, 50134 Florence, Italy., Galdo G; Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, 50134 Florence, Italy., Mazzeo S; Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, 50134 Florence, Italy.; IRCCS Fondazione Don Carlo Gnocchi, 50143 Florence, Italy., Bergamin E; University of Florence, 50134 Florence, Italy., Moschini V; SOD Neurologia I, Dipartmento Neuromuscolo-Scheletrico e degli Organi di Senso, AOU Careggi, 50134 Florence, Italy., Morinelli C; SOD Neurologia I, Dipartmento Neuromuscolo-Scheletrico e degli Organi di Senso, AOU Careggi, 50134 Florence, Italy., Nuti C; University of Florence, 50134 Florence, Italy., De Cristofaro MT; Nuclear Medicine Unit, Azienda Ospedaliero-Universitaria Careggi, 50134 Florence, Italy., Ingannato A; Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, 50134 Florence, Italy., Bagnoli S; Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, 50134 Florence, Italy., Nacmias B; Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, 50134 Florence, Italy.; IRCCS Fondazione Don Carlo Gnocchi, 50143 Florence, Italy., Sorbi S; Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, 50134 Florence, Italy.; IRCCS Fondazione Don Carlo Gnocchi, 50143 Florence, Italy., Bessi V; Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, 50134 Florence, Italy.
Jazyk:	angličtina
Zdroj:	Journal of personalized medicine [J Pers Med] 2023 Jan 25; Vol. 13 (2). Date of Electronic Publication: 2023 Jan 25.
DOI:	10.3390/jpm13020208
Abstrakt:	The aims of the study were to assess empathy deficit and neuronal correlates in logopenic primary progressive aphasia (lv-PPA) and compare these data with those deriving from amnesic Alzheimer's disease (AD). Eighteen lv-PPA and thirty-eight amnesic AD patients were included. Empathy in both cognitive and affective domains was assessed by Informer-rated Interpersonal Reactivity Index (perspective taking, PT, and fantasy, FT, for cognitive empathy; empathic concern, EC, and personal distress, PD, for affective empathy) before (T0) and after (T1) cognitive symptoms' onset. Emotion recognition was explored through the Ekman 60 Faces Test. Cerebral FDG-PET was used to explore neural correlates underlying empathy deficits. From T0 to T1, PT scores decreased, and PD scores increased in both lv-PPA (PT z = -3.43, p = 0.001; PD z = -3.62, p < 0.001) and in amnesic AD (PT z = -4.57, p < 0.001; PD z = -5.20, p < 0.001). Delta PT (T0-T1) negatively correlated with metabolic disfunction of the right superior temporal gyrus, fusiform gyrus, and middle frontal gyrus (MFG) in amnesic AD and of the left inferior parietal lobule (IPL), insula, MFG, and bilateral superior frontal gyrus (SFG) in lv-PPA ( p < 0.005). Delta PD (T0-T1) positively correlated with metabolic disfunction of the right inferior frontal gyrus in amnesic AD ( p < 0.001) and of the left IPL, insula, and bilateral SFG in lv-PPA ( p < 0.005). Lv-PPA and amnesic AD share the same empathic changes, with a damage of cognitive empathy and a heightening of personal distress over time. The differences in metabolic disfunctions correlated with empathy deficits might be due to a different vulnerability of specific brain regions in the two AD clinical presentations. Competing Interests: The authors declare no conflict of interest.
Databáze:	MEDLINE
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